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PMID: 2579891 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine.

Human genetics ·Vol. 69 ·No. 3 ·1985-00-00 ·Pages 233-7

Sutherland GR, Parslow MI, Baker E

Abstract

Two new classes of common fragile site seen in chromosomes from blood lymphocyte cultures are reported. The first class is induced in bands 1q42 and 19q13 by 5-azacytidine (5-AZA). Maximum induction of these fragile sites occurs when the 5-AZA is added 5-8h prior to harvest. The second class is induced in bands 6q13, 9p21, and 10q21 by bromodeoxyuridine (BrdU). In this instance maximum induction occurred if the BrdU was added 4-6h prior to harvest. The known fragile sites, both rare and common, are summarised.

MeSH Terms
Adult Azacitidine/pharmacology Bromodeoxyuridine/pharmacology Chromosome Banding Chromosome Fragile Sites Chromosome Fragility Chromosomes, Human, 19-20 Chromosomes, Human, 6-12 and X Humans Infant, Newborn Karyotyping
Chemicals
Bromodeoxyuridine Azacitidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sutherland G R
Parslow M I
Baker E
References (10)
10 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00293031
Published
1985-00-00
Pages
233-7
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00293031 View journal details
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