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PMID: 2580039 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion.

The Journal of experimental medicine ·Vol. 161 ·No. 4 ·1985-04-01 ·Pages 785-804

Friedman S, Sillcocks D, Rao A, Faas S, Cantor H

Abstract

We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiring an antigen bridge as well as identity at the major histocompatibility complex (I-A) locus. The interaction between the inducer T cell clone and hapten-specific B memory cells results in an early proliferative response and subsequent failure of B cells to secrete antibody in response to T helper cell signals. Possible mechanisms for this novel type of B cell inactivation are explored.

MeSH Terms
Animals Antigen-Presenting Cells/immunology Antigens, Ly/genetics B-Lymphocytes/immunology,metabolism Cell Differentiation Clone Cells/classification,immunology Epitopes Female Histocompatibility Antigens/genetics Histocompatibility Antigens Class II/genetics Immunoglobulin G/biosynthesis Kinetics Lymphocyte Activation Lymphocyte Cooperation Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred DBA Plasma Cells/cytology,metabolism T-Lymphocytes, Helper-Inducer/classification,immunology T-Lymphocytes, Regulatory/classification,immunology Time Factors
Chemicals
Antigens, Ly Epitopes Histocompatibility Antigens Histocompatibility Antigens Class II I-E-antigen Immunoglobulin G
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Friedman S
Sillcocks D
Rao A
Faas S
Cantor H
References (47)
47 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.161.4.785
Published
1985-04-01
Pages
785-804
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189061
Subset
IM
Grants
NIAID NIH HHS · AI 12184 · United States
NIAID NIH HHS · AI 13600 · United States
NCI NIH HHS · CA 26695 · United States
External Links
PubMed source DOI: 10.1084/jem.161.4.785 PMC Full Text View journal details
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