[Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones].

To study the role of genes of Wnt signaling pathway in keratocystic odontogenic tumor (KCOT) of the jaw bones.,Fresh specimens of KCOT and the same patient 's normal oral mucosa were obtained. Then RNA was extracted. Gene chip was used to detect the genes of Wnt signaling pathway.,Compared to normal oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2A down-regulated, FZD3, MAPK10, PRKX and WNT5a up-regulated.,There are abnormal expressions of genes of Wnt pathway in KCOT. Genes of Wnt pathway plays certain roles in KCOT.