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PMID: 25862458 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Eaten alive: novel insights into autophagy from multicellular model systems.

Trends in cell biology ·Vol. 25 ·No. 7 ·2015-07-00 ·Pages 376-87

Zhang H, Baehrecke EH

Abstract

Autophagy delivers cytoplasmic material to lysosomes for degradation. First identified in yeast, the core genes that control this process are conserved in higher organisms. Studies of mammalian cell cultures have expanded our understanding of the core autophagy pathway, but cannot reveal the unique animal-specific mechanisms for the regulation and function of autophagy. Multicellular organisms have different types of cells that possess distinct composition, morphology, and organization of intracellular organelles. In addition, the autophagic machinery integrates signals from other cells and environmental conditions to maintain cell, tissue and organism homeostasis. Here, we highlight how studies of autophagy in flies and worms have identified novel core autophagy genes and mechanisms, and provided insight into the context-specific regulation and function of autophagy.

Keywords
Caenorhabditis elegans Drosophila melanogaster aggrephagy autophagy
MeSH Terms
Animals Autophagy/genetics Caenorhabditis elegans/genetics,metabolism Drosophila melanogaster/genetics,metabolism Gene Expression Regulation Homeostasis Humans Lysosomes/metabolism Models, Biological Organ Specificity Protein Kinases/genetics,metabolism Saccharomyces cerevisiae/genetics,metabolism Signal Transduction Species Specificity Ubiquitins/genetics,metabolism
Chemicals
Ubiquitins Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zhang Hong
Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: [email protected].
Baehrecke Eric H
Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: [email protected].
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2015.03.001
Email
[email protected]
[email protected]
Published
2015-07-00
Epub
2015-00-07
Pages
376-87
Language
English
Region
England
NLM ID
9200566
PMCID
PMC4475674
Subset
IM
Grants
NIGMS NIH HHS · GM079431 · United States
NCI NIH HHS · R01 CA159314 · United States
NCI NIH HHS · CA159314 · United States
NIGMS NIH HHS · R01 GM079431 · United States
NIGMS NIH HHS · GM111658 · United States
NIAID NIH HHS · R01 AI099708 · United States
NIGMS NIH HHS · R01 GM111658 · United States
NIAID NIH HHS · AI099708 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2015.03.001 PMC Full Text View journal details
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