Retinoblastoma. Analysis of 75 cases and proposal for a new model of oncogenesis and tumor growth kinetics.

Ophthalmic paediatrics and genetics ·Vol. 10 ·No. 3 ·1989-09-00 ·Pages 161-71

Mastrangelo D, Di Pisa F, Hadjistilianou T, Bardelli AM, Silvestri S, Frezzotti R

Abstract

A series of 75 retinoblastoma patients were analyzed at the Institute of Ophthalmology, Siena, and a mathematical model for the 'nodule to cancer' transformation applied to it. The authors obtained data in disagreement with Knudson's 'two hit' hypothesis but fitting an alternative model of oncogenesis. This model is based on probabilistic arguments and a possible pattern of tumor growth and evolution is given in detail.

MeSH Terms

Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Eye Neoplasms/classification,etiology,genetics Female Humans Infant Kinetics Male Mathematics Middle Aged Models, Statistical Retinoblastoma/classification,etiology,genetics

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Mastrangelo D

Centro Ricerche Sclavo, Siena, Italy.

Di Pisa F

Hadjistilianou T

Bardelli A M

Silvestri S

Frezzotti R

Article Info

Journal

Ophthalmic paediatrics and genetics

Abbr.

Ophthalmic Paediatr Genet

ISSN

0167-6784

DOI

10.3109/13816818909009872

Published

1989-09-00

Pages

161-71

Language

English

Region

Netherlands

NLM ID

8206832

Subset

External Links

PubMed source DOI: 10.3109/13816818909009872

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