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PMID: 25964382 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Regulation and roles of Ca2+ stores in human sperm.

Reproduction (Cambridge, England) ·Vol. 150 ·No. 2 ·2015-08-00 ·Pages R65-76

Correia J, Michelangeli F, Publicover S

Abstract

[Ca(2)(+)]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2)(+)-permeable plasma membrane ion channel CatSper is central to [Ca(2)(+)]i signalling, but there is good evidence that Ca(2)(+) stored in intracellular organelles is also functionally important. Here we briefly review the current understanding of the diversity of Ca(2)(+) stores and the mechanisms for the regulation of their activity. We then consider the evidence for the involvement of these stores in [Ca(2)(+)]i signalling in mammalian (primarily human) sperm, the agonists that may activate these stores and their role in control of sperm function. Finally we consider the evidence that membrane Ca(2)(+) channels and stored Ca(2)(+) may play discrete roles in the regulation of sperm activities and propose a mechanism by which these different components of the sperm Ca(2)(+)-signalling apparatus may interact to generate complex and spatially diverse [Ca(2)(+)]i signals.

MeSH Terms
Animals Calcium/metabolism,physiology Calcium Channels/metabolism Calcium Signaling/drug effects,physiology Cell Membrane/physiology Humans Male Spermatozoa/metabolism,physiology
Chemicals
Calcium Channels Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Correia Joao
School of BiosciencesUniversity of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Michelangeli Francesco
School of BiosciencesUniversity of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Publicover Stephen
School of BiosciencesUniversity of Birmingham, Edgbaston, Birmingham B15 2TT, UK [email protected].
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Article Info
Journal
Reproduction (Cambridge, England)
Abbr.
Reproduction
ISSN
1741-7899
DOI
10.1530/REP-15-0102
Email
[email protected]
Published
2015-08-00
Epub
2015-00-11
Pages
R65-76
Language
English
Region
England
NLM ID
100966036
PMCID
PMC4497595
Subset
IM
Grants
Wellcome Trust · 086470 · United Kingdom
External Links
PubMed source DOI: 10.1530/REP-15-0102 PMC Full Text View journal details
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