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PMID: 26041457 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

ER-endosome contact sites: molecular compositions and functions.

The EMBO journal ·Vol. 34 ·No. 14 ·2015-07-14 ·Pages 1848-58

Raiborg C, Wenzel EM, Stenmark H

Abstract

Recent studies have revealed the existence of numerous contact sites between the endoplasmic reticulum (ER) and endosomes in mammalian cells. Such contacts increase during endosome maturation and play key roles in cholesterol transfer, endosome positioning, receptor dephosphorylation, and endosome fission. At least 7 distinct contact sites between the ER and endosomes have been identified to date, which have diverse molecular compositions. Common to these contact sites is that they impose a close apposition between the ER and endosome membranes, which excludes membrane fusion while allowing the flow of molecular signals between the two membranes, in the form of enzymatic modifications, or ion, lipid, or protein transfer. Thus, ER-endosome contact sites ensure coordination of molecular activities between the two compartments while keeping their general compositions intact. Here, we review the molecular architectures and cellular functions of known ER-endosome contact sites and discuss their implications for human health.

Keywords
endoplasmic reticulum endosome membrane contact sites
MeSH Terms
Animals Cell Membrane/metabolism Cytoskeleton/metabolism Endoplasmic Reticulum/chemistry,metabolism Endosomes/chemistry,metabolism Humans Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism
Chemicals
PTPN1 protein, human Protein Tyrosine Phosphatase, Non-Receptor Type 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Raiborg Camilla
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research Oslo University Hospital, Oslo, Norway.
Wenzel Eva M
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research Oslo University Hospital, Oslo, Norway.
Stenmark Harald
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Molecular Cell Biology, Institute for Cancer Research Oslo University Hospital, Oslo, Norway Centre of Molecular Inflammation Research, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway [email protected].
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.15252/embj.201591481
Email
[email protected]
Published
2015-07-14
Epub
2015-00-03
Pages
1848-58
Language
English
Region
England
NLM ID
8208664
PMCID
PMC4547891
Subset
IM
External Links
PubMed source DOI: 10.15252/embj.201591481 PMC Full Text View journal details
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