Home LiteratureArticle Details
PMID: 26077119 Published · ppublish English Journal Article

Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico ·Vol. 17 ·No. 10 ·2015-10-00 ·Pages 810-8

Zhang Y, Jiang C, Li J, Sun J, Qu X

Abstract

Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were immune response-related indicators. Preoperative NLR and PLR had been considered to be related to the prognosis of various cancers. The objective of this study was to evaluate the prognostic significance of NLR and PLR in patients with gallbladder carcinoma (GBC). From 2001 to 2013, 145 patients with GBC were recruited in this retrospective study. Cutoff values of NLR and PLR were determined by receiver operating characteristic curves (ROC). The correlation of clinical data, including tumor differentiation, nevin stage, TNM stage, operation margin, operation mode, NLR, PLR, hemoglobin, C reactive protein (CRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 199 (CA199) with median survival period of patients was analyzed by univariate survival analysis. The multivariate prognosis analysis was performed to select the independent prognostic factors. The cutoff values of NLR and PLR were 1.94 and 113.34, respectively. Compared with low NLR and low PLR group, the 5-year survival rates in high NLR and high PLR group were reduced (P < 0.05). The degree of tumor differentiation, nevin stage, TNM stage, operation mode, NLR, PLR, CA199, total bilirubin, CRP and CEA were associated with the median survival period of patients (P < 0.01). The multivariate prognosis analysis showed that NLR, nevin stage, operation mode and hemoglobin were independent prognostic factors (P < 0.05). Preoperative NLR and PLR were closely related to prognosis of patients with GBC and might be useful for the evaluation of prognosis of patients with GBC.

Keywords
Five-year survival rate Gallbladder cancer Neutrophil/lymphocyte ratio Platelet/lymphocyte ratio Prognosis
MeSH Terms
Adenocarcinoma/blood,pathology,surgery Aged Blood Platelets C-Reactive Protein/metabolism CA-19-9 Antigen/blood Carcinoembryonic Antigen/blood Carcinoma, Adenosquamous/blood,pathology,surgery Carcinoma, Squamous Cell/blood,pathology,surgery Female Gallbladder Neoplasms/blood,pathology,surgery Humans Leukocyte Count Lymphocyte Count Lymphocytes Male Middle Aged Multivariate Analysis Neoplasm Staging Neutrophils Platelet Count Preoperative Period Prognosis ROC Curve Retrospective Studies Survival Analysis
Chemicals
CA-19-9 Antigen Carcinoembryonic Antigen C-Reactive Protein
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zhang Y
Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China. | Department of Pathology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.
Jiang C
Department of Pathology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.
Li J
Central Laboratory, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266011, Shandong, China.
Sun J
Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China.
Qu X
Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, 250012, Shandong, People's Republic of China. [email protected].
References (29)
29 references, click to expand
  1. Serum total bilirubin elevation is a predictor of the clinicopathological severity of acute appendicitis.
    Surg Today. 2014 Jun;44(6):1104-8 PMID: 23880964
  2. Improving the accuracy of pre-operative survival prediction in renal cell carcinoma with C-reactive protein.
    Br J Cancer. 2010 Nov 23;103(11):1649-56 PMID: 21063409
  3. Topical ALA-PDT modifies neutrophils' chemiluminescence, lymphocytes' interleukin-1beta secretion and serum level of transforming growth factor beta1 in patients with nonmelanoma skin malignancies A clinical study.
    Photodiagnosis Photodyn Ther. 2005 Mar;2(1):65-72 PMID: 25048558
  4. Preoperative platelet lymphocyte ratio as an independent prognostic marker in ovarian cancer.
    Clin Transl Oncol. 2011 Jul;13(7):499-503 PMID: 21775277
  5. Gallbladder cancer: differences in presentation, surgical treatment, and survival in patients treated at centers in three countries.
    J Am Coll Surg. 2011 Jan;212(1):50-61 PMID: 21075015
  6. Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis.
    Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1204-12 PMID: 24793958
  7. [Establishment of liver metastasis model of human gallbladder cancer and isolation of the subpopulation with high metastatic potential].
    Zhonghua Yi Xue Za Zhi. 2006 Aug 15;86(30):2117-21 PMID: 17064616
  8. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of survival and metastasis for recurrent hepatocellular carcinoma after transarterial chemoembolization.
    PLoS One. 2015 Mar 05;10(3):e0119312 PMID: 25742141
  9. Long-term results after resection for gallbladder cancer. Implications for staging and management.
    Ann Surg. 1996 Nov;224(5):639-46 PMID: 8916879
  10. Tumor-associated neutrophils: new targets for cancer therapy.
    Cancer Res. 2011 Apr 1;71(7):2411-6 PMID: 21427354
  11. The immunobiology of cancer immunosurveillance and immunoediting.
    Immunity. 2004 Aug;21(2):137-48 PMID: 15308095
  12. Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.
    PLoS One. 2013 Aug 21;8(8):e73609 PMID: 23991201
  13. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients.
    Ann Surg Oncol. 2012 Jan;19(1):217-24 PMID: 21638095
  14. Platelets increase the proliferation of ovarian cancer cells.
    Blood. 2012 Dec 6;120(24):4869-72 PMID: 22966171
  15. Preoperative C-reactive protein as a prognostic and therapeutic marker for colorectal cancer.
    J Surg Oncol. 2008 Dec 1;98(7):540-4 PMID: 18937231
  16. The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma.
    BMC Cancer. 2013 Feb 02;13:52 PMID: 23374755
  17. Evaluation of two inflammation-based prognostic scores in patients with resectable gallbladder carcinoma.
    Ann Surg Oncol. 2014 Feb;21(2):449-57 PMID: 24081806
  18. Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.
    Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81 PMID: 22826226
  19. Carcinoma of the gallbladder: staging, treatment, and prognosis.
    Cancer. 1976 Jan;37(1):141-8 PMID: 1247951
  20. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis.
    J Natl Cancer Inst. 2014 May 29;106(6):dju124 PMID: 24875653
  21. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer.
    Future Oncol. 2010 Jan;6(1):149-63 PMID: 20021215
  22. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM.
    Ann Surg Oncol. 2010 Jun;17(6):1471-4 PMID: 20180029
  23. Frequency of gall bladder carcinoma in patients with acute and chronic cholecystitis.
    J Ayub Med Coll Abbottabad. 2014 Apr-Jun;26(2):191-3 PMID: 25603675
  24. Pretreatment neutrophil-lymphocyte ratio: an independent predictor of survival in patients with hepatocellular carcinoma.
    Medicine (Baltimore). 2015 Mar;94(11):e639 PMID: 25789957
  25. Contribution of platelets to tumour metastasis.
    Nat Rev Cancer. 2011 Feb;11(2):123-34 PMID: 21258396
  26. Prognostic role of neutrophil-lymphocyte ratio in operable esophageal squamous cell carcinoma.
    World J Gastroenterol. 2015 May 14;21(18):5591-7 PMID: 25987784
  27. Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome.
    Pancreas. 2006 Jan;32(1):22-8 PMID: 16340740
  28. Predictive power of prothrombin time and serum total bilirubin for postoperative mortality after major hepatectomy with extrahepatic bile duct resection.
    Surgery. 2014 Mar;155(3):504-11 PMID: 24287146
  29. Gallbladder carcinoma.
    Eur J Surg Oncol. 2008 Mar;34(3):306-12 PMID: 17964753
Article Info
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Abbr.
Clin Transl Oncol
ISSN
1699-3055
DOI
10.1007/s12094-015-1310-2
Email
[email protected]
Published
2015-10-00
Epub
2015-00-16
Pages
810-8
Language
English
Region
Italy
NLM ID
101247119
Subset
IM
External Links
PubMed source DOI: 10.1007/s12094-015-1310-2 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2