Home LiteratureArticle Details
PMID: 26343387 Published · ppublish English Journal Article Meta-Analysis

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Nature genetics ·Vol. 47 ·No. 10 ·2015-10-00 ·Pages 1121-1130

Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Bottinger EP, Buring JE, Chambers JC, Collins R, Cupples LA, Danesh J, Demuth I, Elosua R, Epstein SE, Esko T, Feitosa MF, Franco OH, Franzosi MG, Granger CB, Gu D, Gudnason V, Hall AS, Hamsten A, Harris TB, Hazen SL, Hengstenberg C, Hofman A, Ingelsson E, Iribarren C, Jukema JW, Karhunen PJ, Kim BJ, Kooner JS, Kullo IJ, Lehtimäki T, Loos RJF, Melander O, Metspalu A, März W, Palmer CN, Perola M, Quertermous T, Rader DJ, Ridker PM, Ripatti S, Roberts R, Salomaa V, Sanghera DK, Schwartz SM, Seedorf U, Stewart AF, Stott DJ, Thiery J, Zalloua PA, O'Donnell CJ, Reilly MP, Assimes TL, Thompson JR, Erdmann J, Clarke R, Watkins H, Kathiresan S, McPherson R, Deloukas P, Schunkert H, Samani NJ, Farrall M

Abstract

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.

MeSH Terms
Coronary Artery Disease/genetics Genome, Human Genome-Wide Association Study Humans Phenotype
Authors & Affiliations
151 authors, click to expand affiliations / ORCID
Nikpay Majid
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.
Goel Anuj
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Won Hong-Hee
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA. | Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. | Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. | Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Hall Leanne M
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Willenborg Christina
Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany. | DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Lübeck, Germany.
Kanoni Stavroula
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Saleheen Danish
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. | Center for Non-Communicable Diseases, Karachi, Pakistan.
Kyriakou Theodosios
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Nelson Christopher P
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. | NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Hopewell Jemma C
CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Webb Thomas R
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. | NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Zeng Lingyao
Deutsches Herzzentrum München, Technische Universität München, München, Germany. | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, München, Germany.
Dehghan Abbas
Department of Epidemiology, Erasmus University Medical center, Rotterdam, The Netherlands.
Alver Maris
Estonian Genome Center, University of Tartu, Tartu, Estonia. | Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Armasu Sebastian M
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Auro Kirsi
Department of Health, National Institute for Health and Welfare, Helsinki, Finland. | Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. | Diabetes & Obesity Research Program, University of Helsinki, Helsinki, Finland.
Bjonnes Andrew
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA. | Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Chasman Daniel I
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. | Harvard Medical School, Boston, Massachusetts, USA.
Chen Shufeng
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ford Ian
Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Franceschini Nora
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Gieger Christian
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, München, Germany. | Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. | Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Grace Christopher
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Gustafsson Stefan
Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. | Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Huang Jie
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Hwang Shih-Jen
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. | Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Kim Yun Kyoung
Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Korea.
Kleber Marcus E
Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany.
Lau King Wai
CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Lu Xiangfeng
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lu Yingchang
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. | The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lyytikäinen Leo-Pekka
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. | Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Mihailov Evelin
Estonian Genome Center, University of Tartu, Tartu, Estonia.
Morrison Alanna C
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Pervjakova Natalia
Estonian Genome Center, University of Tartu, Tartu, Estonia. | Department of Health, National Institute for Health and Welfare, Helsinki, Finland. | Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. | Diabetes & Obesity Research Program, University of Helsinki, Helsinki, Finland.
Qu Liming
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Rose Lynda M
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Salfati Elias
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Saxena Richa
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA. | Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. | Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Scholz Markus
Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany. | LIFE Research Center of Civilization Diseases, Leipzig, Germany.
Smith Albert V
Icelandic Heart Association, Kopavogur, Iceland. | Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Tikkanen Emmi
Department of Public Health, University of Helsinki, Helsinki, Finland. | Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Uitterlinden Andre
Department of Epidemiology, Erasmus University Medical center, Rotterdam, The Netherlands.
Yang Xueli
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang Weihua
Department of Epidemiology and Biostatistics, Imperial College London, London, UK. | Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK.
Zhao Wei
Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
de Andrade Mariza
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
de Vries Paul S
Department of Epidemiology, Erasmus University Medical center, Rotterdam, The Netherlands.
van Zuydam Natalie R
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. | Medical Research Institute, University of Dundee, Dundee, UK.
Anand Sonia S
Population Health Research Institute, Hamilton Health Sciences, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Bertram Lars
Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany. | Neuroepidemiology and Ageing Research Unit, School of Public Health, Faculty of Medicine, The Imperial College of Science, Technology, and Medicine, London, UK.
Beutner Frank
LIFE Research Center of Civilization Diseases, Leipzig, Germany. | Heart Center Leipzig, Cardiology, University of Leipzig, Leipzig, Germany.
Dedoussis George
Department of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Frossard Philippe
Center for Non-Communicable Diseases, Karachi, Pakistan.
Gauguier Dominique
INSERM, UMRS1138, Centre de Recherche des Cordeliers, Paris, France.
Goodall Alison H
NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. | Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK.
Gottesman Omri
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Haber Marc
Lebanese American University, School of Medicine, Beirut, Lebanon.
Han Bok-Ghee
Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Korea.
Huang Jianfeng
Hypertension Division, Fuwai Hospital, National Center For Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jalilzadeh Shapour
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Kessler Thorsten
Deutsches Herzzentrum München, Technische Universität München, München, Germany. | Klinikum rechts der Isar, München, Germany.
König Inke R
DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Lübeck, Germany. | Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, Germany.
Lannfelt Lars
Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Lieb Wolfgang
Institut für Epidemiologie, Christian-Albrechts Universität zu Kiel, Kiel, Germany.
Lind Lars
Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden.
Lindgren Cecilia M
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. | Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA.
Lokki Marja-Liisa
Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Magnusson Patrik K
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mallick Nadeem H
Punjab Institute of Cardiology, Lahore, Pakistan.
Mehra Narinder
All India Institute of Medical Sciences, New Delhi, India.
Meitinger Thomas
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, München, Germany. | Institut für Humangenetik, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. | Institute of Human Genetics, Technische Universität München, München, Germany.
Memon Fazal-Ur-Rehman
Red Crescent Institute of Cardiology, Hyderabad, Pakistan.
Morris Andrew P
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. | Department of Biostatistics, University of Liverpool, Liverpool, UK.
Nieminen Markku S
Department of Medicine, Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Pedersen Nancy L
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Peters Annette
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, München, Germany. | Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Rallidis Loukianos S
Second Department of Cardiology, Attikon Hospital, School of Medicine, University of Athens, Athens, Greece.
Rasheed Asif
Center for Non-Communicable Diseases, Karachi, Pakistan. | Red Crescent Institute of Cardiology, Hyderabad, Pakistan.
Samuel Maria
Center for Non-Communicable Diseases, Karachi, Pakistan.
Shah Svati H
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Sinisalo Juha
Department of Medicine, Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Stirrups Kathleen E
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. | Department of Haematology, University of Cambridge, Cambridge, UK.
Trompet Stella
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. | Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Wang Laiyuan
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. | National Human Genome Center at Beijing, Beijing, China.
Zaman Khan S
National Institue of Cardiovascular Diseases, Karachi, Pakistan.
Ardissino Diego
Division of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. | Associazione per lo Studio della Trombosi in Cardiologia, Pavia, Italy.
Boerwinkle Eric
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA. | Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
Borecki Ingrid B
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Bottinger Erwin P
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Buring Julie E
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Chambers John C
Department of Epidemiology and Biostatistics, Imperial College London, London, UK. | Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK. | Imperial College Healthcare NHS Trust, London, UK.
Collins Rory
CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Cupples L Adrienne
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. | Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Danesh John
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. | Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Demuth Ilja
The Berlin Aging Study II; Research Group on Geriatrics; Charité - Universitätsmedizin Berlin, Berlin, Germany. | Institute of Medical and Human Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Elosua Roberto
Grupo de Epidemiología y Genética Cardiovascular, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.
Epstein Stephen E
MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA.
Esko Tõnu
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA. | Estonian Genome Center, University of Tartu, Tartu, Estonia. | Division of Endocrinology and Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, USA. | Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Feitosa Mary F
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.
Franco Oscar H
Department of Epidemiology, Erasmus University Medical center, Rotterdam, The Netherlands.
Franzosi Maria Grazia
Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Granger Christopher B
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Gu Dongfeng
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Gudnason Vilmundur
Icelandic Heart Association, Kopavogur, Iceland. | Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Hall Alistair S
Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK.
Hamsten Anders
Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Harris Tamara B
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Hazen Stanley L
Cleveland Clinic, Cleveland, Ohio, USA.
Hengstenberg Christian
Deutsches Herzzentrum München, Technische Universität München, München, Germany. | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, München, Germany.
Hofman Albert
Department of Epidemiology, Erasmus University Medical center, Rotterdam, The Netherlands.
Ingelsson Erik
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. | Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. | Science for Life Laboratory, Uppsala University, Uppsala, Sweden. | Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.
Iribarren Carlos
Kaiser Permanente Division of Research, Oakland, California, USA.
Jukema J Wouter
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. | Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands. | Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
Karhunen Pekka J
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. | Department of Forensic Medicine, University of Tampere School of Medicine, Tampere, Finland.
Kim Bong-Jo
Center for Genome Science, Korea National Institute of Health, Chungcheongbuk-do, Korea.
Kooner Jaspal S
Department of Cardiology, Ealing Hospital NHS Trust, Middlesex, UK. | Imperial College Healthcare NHS Trust, London, UK. | Cardiovascular Science, National Heart and Lung Institute, Imperial College London, London, UK.
Kullo Iftikhar J
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Lehtimäki Terho
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. | Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland.
Loos Ruth J F
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. | The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. | The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Melander Olle
Department of Clinical Sciences, Hypertension and Cardiovascular Disease, Lund University, University Hospital Malmö, Malmö, Sweden.
Metspalu Andres
Estonian Genome Center, University of Tartu, Tartu, Estonia. | Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
März Winfried
Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany. | Synlab Academy, Synlab Services GmbH, Mannheim, Germany. | Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Palmer Colin N
Medical Research Institute, University of Dundee, Dundee, UK.
Perola Markus
Estonian Genome Center, University of Tartu, Tartu, Estonia. | Department of Health, National Institute for Health and Welfare, Helsinki, Finland. | Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. | Diabetes & Obesity Research Program, University of Helsinki, Helsinki, Finland.
Quertermous Thomas
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA. | Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.
Rader Daniel J
Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. | Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ridker Paul M
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. | Harvard Medical School, Boston, Massachusetts, USA.
Ripatti Samuli
Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. | Department of Public Health, University of Helsinki, Helsinki, Finland. | Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
Roberts Robert
University of Ottawa Heart Institute, Ottawa, Canada.
Salomaa Veikko
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Sanghera Dharambir K
Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. | Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. | Oklahoma Center for Neuroscience, Oklahoma City, Oklahoma, USA.
Schwartz Stephen M
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. | Department of Epidemiology, University of Washington, Seattle, Washington, USA.
Seedorf Udo
Department of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stewart Alexandre F
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.
Stott David J
Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Thiery Joachim
LIFE Research Center of Civilization Diseases, Leipzig, Germany. | Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Medical Faculty, Leipzig, Germany.
Zalloua Pierre A
Lebanese American University, School of Medicine, Beirut, Lebanon. | Harvard School of Public Health, Boston, Massachusetts, USA.
O'Donnell Christopher J
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. | National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda, Maryland, USA. | Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.
Reilly Muredach P
Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Assimes Themistocles L
Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA. | Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.
Thompson John R
Department of Health Sciences, University of Leicester, Leicester, UK.
Erdmann Jeanette
Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany. | DZHK (German Research Center for Cardiovascular Research) partner site Hamburg-Lübeck-Kiel, Lübeck, Germany.
Clarke Robert
CTSU, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Watkins Hugh
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Kathiresan Sekar
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA. | Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. | Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. | Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
McPherson Ruth
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada.
Deloukas Panos
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. | Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Schunkert Heribert
Deutsches Herzzentrum München, Technische Universität München, München, Germany. | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, München, Germany.
Samani Nilesh J
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. | NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
Farrall Martin
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. | Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Investigators
151 investigators, click to expand
Nikpay Majid
Goel Anuj
Won Hong-Hee
Hall Leanne M
Willenborg Christina
Kanoni Stavroula
Saleheen Danish
Kyriakou Theodosios
Nelson Christopher P
Hopewell Jemma C
Webb Thomas R
Zeng Lingyao
Dehghan Abbas
Alver Maris
Armasu Sebastian M
Auro Kirsi
Bjonnes Andrew
Chasman Daniel I
Chen Shufeng
Ford Ian
Franceschini Nora
Gieger Christian
Grace Christopher
Gustafsson Stefan
Huang Jie
Hwang Shih-Jen
Kim Yun Kyoung
Kleber Marcus E
Lau King Wai
Lu Xiangfeng
Lu Yingchang
Lyytikäinen Leo-Pekka
Mihailov Evelin
Morrison Alanna C
Pervjakova Natalia
Qu Liming
Rose Lynda M
Salfati Elias
Saxena Richa
Scholz Markus
Smith Albert V
Tikkanen Emmi
Uitterlinden Andre
Yang Xueli
Zhang Weihua
Zhao Wei
de Andrade Mariza
de Vries Paul S
van Zuydam Natalie R
Anand Sonia S
Bertram Lars
Beutner Frank
Dedoussis George
Frossard Philippe
Gauguier Dominique
Goodall Alison H
Gottesman Omri
Haber Marc
Han Bok-Ghee
Huang Jianfeng
Jalilzadeh Shapour
Kessler Thorsten
König Inke R
Lannfelt Lars
Lieb Wolfgang
Lind Lars
Lindgren Cecilia M
Lokki Marja-Liisa
Magnusson Patrik K
Mallick Nadeem H
Mehra Narinder
Meitinger Thomas
Memon Fazal-Ur-Rehman
Morris Andrew P
Nieminen Markku S
Pedersen Nancy L
Peters Annette
Rallidis Loukianos S
Rasheed Asif
Samuel Maria
Shah Svati H
Sinisalo Juha
Stirrups Kathleen E
Trompet Stella
Wang Laiyuan
Zaman Khan S
Ardissino Diego
Boerwinkle Eric
Borecki Ingrid B
Bottinger Erwin P
Buring Julie E
Chambers John C
Collins Rory
Cupples L Adrienne
Danesh John
Demuth Ilja
Elosua Roberto
Epstein Stephen E
Esko Tõnu
Feitosa Mary F
Franco Oscar H
Franzosi Maria Grazia
Granger Christopher B
Gu Dongfeng
Gudnason Vilmundur
Hall Alistair S
Hamsten Anders
Harris Tamara B
Hazen Stanley L
Hengstenberg Christian
Hofman Albert
Ingelsson Erik
Iribarren Carlos
Jukema J Wouter
Karhunen Pekka J
Kim Bong-Jo
Kooner Jaspal S
Kullo Iftikhar J
Lehtimäki Terho
Loos Ruth J F
Melander Olle
Metspalu Andres
März Winfried
Palmer Colin N
Perola Markus
Quertermous Thomas
Rader Daniel J
Ridker Paul M
Ripatti Samuli
Roberts Robert
Salomaa Veikko
Sanghera Dharambir K
Schwartz Stephen M
Seedorf Udo
Stewart Alexandre F
Stott David J
Thiery Joachim
Zalloua Pierre A
O'Donnell Christopher J
Reilly Muredach P
Assimes Themistocles L
Thompson John R
Erdmann Jeanette
Clarke Robert
Watkins Hugh
Kathiresan Sekar
McPherson Ruth
Deloukas Panos
Schunkert Heribert
Samani Nilesh J
Farrall Martin
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.3396
Published
2015-10-00
Epub
2015-00-07
Pages
1121-1130
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC4589895
Subset
IM
Grants
British Heart Foundation · RG/08/014/24067 · United Kingdom
NHLBI NIH HHS · R01 HL127564 · United States
NIDDK NIH HHS · R01 DK107437 · United States
NHLBI NIH HHS · R33 HL120757 · United States
NCI NIH HHS · UM1 CA182913 · United States
British Heart Foundation · RG/14/5/30893 · United Kingdom
NHLBI NIH HHS · R01 HL117078 · United States
Medical Research Council · MR/L01629X/1 · United Kingdom
Medical Research Council · MR/L003120/1 · United Kingdom
British Heart Foundation · RE/13/1/30181 · United Kingdom
NIDDK NIH HHS · R01 DK089256 · United States
British Heart Foundation · FS/14/55/30806 · United Kingdom
External Links
PubMed source DOI: 10.1038/ng.3396 PMC Full Text View journal details
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