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PMID: 263439 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

X-linked mental retardation: transmission of the trait by an apparently unaffected male.

American journal of medical genetics ·Vol. 2 ·No. 3 ·1978-00-00 ·Pages 217-24

Wolff G, Hameister H, Ropers HH

Abstract

A pedigree is presented in which an apparently unaffected man transmitted the gene for X-linked mental retardation to at least four of his 12 daughters. None of his 12 sons was mentally retarded. These findings may be explained by a somatic mutation and germinal mosaicism in the father or by a half chromatid mutation in maternal gametes.

MeSH Terms

Adult Aged Female Humans Intellectual Disability/genetics Male Middle Aged Mosaicism Mutation Pedigree Sex Factors X Chromosome

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wolff G

Hameister H

Ropers H H

Article Info

Journal

American journal of medical genetics

Abbr.

Am J Med Genet

ISSN

0148-7299

DOI

10.1002/ajmg.1320020302

Published

1978-00-00

Pages

217-24

Language

English

Region

United States

NLM ID

7708900

Subset

External Links

PubMed source DOI: 10.1002/ajmg.1320020302

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X-linked mental retardation: transmission of the trait by an apparently unaffected male.

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