SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer.

Molecular cell ·Vol. 59 ·No. 6 ·2015-12-22

Duan Shanshan, Pagano Michele

Abstract

In this issue, An et al. (2015) and Gan et al. (2015) reveal that the CRL3(SPOP) ubiquitin ligase mediates the degradation of the transcription factor ERG and that translocations of ERG or mutations in SPOP prevent CRL3(SPOP)-dependent degradation of ERG in prostate cancer cells.

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

Published

2015-12-22

Indexed

2015-09-19

Updated

2016-11-22

Language

English

Country/Region

United States

NLM ID

9802571

External Links

PubMed source View journal details

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SPOP Mutations or ERG Rearrangements Result in Enhanced Levels of ERG to Promote Cell Invasion in Prostate Cancer.

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