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PMID: 264684 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Genetic control of mitochondrial malate dehydrogenases: evidence for duplicated chromosome segments.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 1 ·1977-01-00 ·Pages 310-4

Yang NS, Sorenson JC, Scandalios JG

Abstract

The genetic control of the major mitochondrial isoenzymes of malate dehydrogenase (L-malate:NAD+ oxidoreductase; EC 1.1.1.37) has been investigated in Zea mays. The mitochondrial isozymes are coded at four nuclear gene loci. Two of the loci (mdh1 and mdh2) are diallelic and tightly linked. The other two loci (mdh3 and mdh4) appear to have arisen by duplication of the chromosome segment carrying mdh1 and mdh2, but are not linked to them. The segregation of such a duplicate segment can explain anomalous backcross and F2 segregation ratios.

MeSH Terms
Alleles Biological Evolution Chromosome Aberrations Cytoplasm/enzymology Genes Genetic Linkage Isoenzymes/metabolism Malate Dehydrogenase/metabolism Mitochondria/enzymology Models, Biological Zea mays/enzymology
Chemicals
Isoenzymes Malate Dehydrogenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yang N S
Sorenson J C
Scandalios J G
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.1.310
Published
1977-01-00
Pages
310-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC393249
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.1.310 PMC Full Text View journal details
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