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PMID: 2649507 Published · ppublish English Journal Article Review

Astrocytes and intracerebral immune responses.

Journal of clinical immunology ·Vol. 9 ·No. 1 ·1989-01-00 ·Pages 1-9

Frohman EM, van den Noort S, Gupta S

Abstract

The astrocyte is the most abundant cell within the central nervous system (CNS). This cell subserves a multiplicity of important functions that contribute to the process of neural development as well as to the integrity of normal brain function. Adding to the already exhaustive list of capabilities, the astrocyte has now been demonstrated to function as an intracerebral antigen presenting cell. These findings are serving to revise our view of the brain as an immunoprivileged site and perhaps will shed some light on the pathogenetic mechanisms involved in a number of CNS disorders of immune dysregulation. In this review we provide some perspective on the regulatory mechanisms that influence astrocyte immune functions. Specifically, we address the role played by the major histocompatibility complex (MHC) antigens as well as adhesion molecules in the initiation of brain immune responses.

MeSH Terms
Animals Antigen-Presenting Cells/immunology Antigens, Differentiation/immunology Antigens, Surface/immunology Astrocytes/immunology Blood-Brain Barrier Brain/immunology,physiology Cell Adhesion Cell Adhesion Molecules Encephalomyelitis, Autoimmune, Experimental/immunology Histocompatibility Antigens Class II/biosynthesis Humans Lymphocyte Function-Associated Antigen-1 Multiple Sclerosis/immunology
Chemicals
Antigens, Differentiation Antigens, Surface Cell Adhesion Molecules Histocompatibility Antigens Class II Lymphocyte Function-Associated Antigen-1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Frohman E M
Department of Neurology, College of Medicine, University of California, Irvine 92717.
van den Noort S
Gupta S
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00917121
Published
1989-01-00
Pages
1-9
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00917121 View journal details
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