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PMID: 265535 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Lymphocytes alloantigens associated with X-chromosome-linked immune response genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 2 ·1977-02-00 ·Pages 721-4

Zeicher M, Mozes E, Lonai P

Abstract

A new polymorphic alloantigen system controlled by loci on the X-chromosome has been identified by using antisera from F1 hybrid mice differing in their X-chromosome. These alloantigens are associated with the X-chromosome. These alloantigens are associated with the X-linked immune response genes controlling the immune response to the so-called "thymus independent antigens" such as type III pneumococcal polysaccharide, poly(I)-poly(C), and denatured DNA. They also show association with the histocompatibility locus present on the X-chromosome. They were mainly detected on a not yet characterized thymus-derived lymphocyte subpopulation. A certain similarity with the major histocompatibility complex of the mouse supports the possibility of additional I-like regions besides the I region of the histocompatibility-2 complex.

MeSH Terms
Animals Antibody Formation Female Genes Hybridization, Genetic Isoantigens Lymphocytes/immunology Male Mice Mice, Inbred Strains Recombination, Genetic Sex Chromosomes/immunology
Chemicals
Isoantigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zeicher M
Mozes E
Lonai P
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.2.721
Published
1977-02-00
Pages
721-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392365
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.2.721 PMC Full Text View journal details
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