Varicocele as a source of male infertility - current treatment techniques.
To establish the extent of varicocele as the cause of infertility in men and compare the various techniques of treatment. We searched PubMed and the Cochrane Library database using varicocele, male infertility, varicocelectomy as keywords. Varicocele seems to be a growing problem considered to be one of the most common causes of male infertility in recent times. Nevertheless, its role remains unclear. The best treatment option seems to be microscopic surgery - the most effective and linked to rare surgical complications. But the greatest clinical problem remains the selection of patients to treat - recently it is believed that varicocelectomy is a possibly advisable option in patients with clinical varicocele and seminal parameter impairment [1]. More high-quality, multicenter, long-term randomized controlled trials (RCT's) are required to verify the findings.
29 references, click to expand
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Adolescent varicocelectomy: does artery sparing influence recurrence rate and/or catch-up growth?Andrology. 2014 Mar;2(2):159-64 PMID: 24339439
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Varicocelectomy for infertile couples with advanced paternal age.Urology. 2008 Jul;72(1):109-13 PMID: 18384862
-
Effect of varicocele on sperm function and semen oxidative stress.BJU Int. 2012 Jan;109(2):259-65 PMID: 21592296
-
Evolving approach to the varicocele.Urol Clin North Am. 2008 May;35(2):183-9, viii PMID: 18423239
-
Testicular blood flow and fluid dynamics in monkeys with surgically induced varicoceles.J Androl. 1983 Jul-Aug;4(4):256-60 PMID: 6618996
-
Are varicoceles associated with increased deoxyribonucleic acid fragmentation?Fertil Steril. 2011 Dec;96(6):1283-7 PMID: 22035729
-
Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trial.Eur Urol. 2011 Mar;59(3):455-61 PMID: 21196073
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Older age is associated with similar improvements in semen parameters and testosterone after subinguinal microsurgical varicocelectomy.J Urol. 2011 Feb;185(2):620-5 PMID: 21168880
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Role of oxidative stress in pathogenesis of varicocele and infertility.Urology. 2009 Mar;73(3):461-9 PMID: 19167039
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Treatment of palpable varicocele in infertile men: a meta-analysis to define the best technique.J Androl. 2009 Jan-Feb;30(1):33-40 PMID: 18772487
-
Microsurgical treatment of persistent or recurrent varicocele.Fertil Steril. 2004 Sep;82(3):718-22 PMID: 15374720
-
Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele.J Androl. 2010 May-Jun;31(3):299-305 PMID: 20019389
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The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele.BJU Int. 1999 Dec;84(9):1046-9 PMID: 10571633
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Surgery or embolisation for varicocele in subfertile men.Cochrane Database Syst Rev. 2004;(3):CD000479 PMID: 15266431
-
Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis.Fertil Steril. 2007 Sep;88(3):639-48 PMID: 17434508
-
Reduction in testicular temperature after varicocelectomy in infertile men.Urology. 1997 Aug;50(2):257-9 PMID: 9255298
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Relationship between oxidative stress, varicocele and infertility: a meta-analysis.Reprod Biomed Online. 2006 May;12(5):630-3 PMID: 16790111
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Adolescent varicocele repair: long-term results and comparison of surgical techniques according to optical magnification use in 100 cases at a single university hospital.J Urol. 2005 Nov;174(5):2003-6; discussion 2006-7 PMID: 16217378
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Patterns of infertility in Poland - multicenter study.Neuro Endocrinol Lett. 2011;32(6):799-804 PMID: 22286797
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Detrimental effect of left varicocele on the reproductive capacity of the early haploid male gamete.J Urol. 1996 Jul;156(1):267-70 PMID: 8648820
-
Inhibition of testicular testosterone biosynthesis following experimental varicocele in rats.Biol Reprod. 1987 May;36(4):933-7 PMID: 3593858
-
Open non-microsurgical, laparoscopic or open microsurgical varicocelectomy for male infertility: a meta-analysis of randomized controlled trials.BJU Int. 2012 Nov;110(10):1536-42 PMID: 22642226
-
Review of current varicocelectomy techniques and their outcomes.BJU Int. 2011 Oct;108(7):1157-72 PMID: 21435155
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Laparoscopic varicocelectomy in infertile men: does age matter?Urol Int. 2013;91(2):192-6 PMID: 23838535
-
Current issues in varicocele management: a review.World J Mens Health. 2013 Apr;31(1):12-20 PMID: 23658861
-
The role of oxidative stress and antioxidants in male fertility.Cent European J Urol. 2013;66(1):60-7 PMID: 24578993
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The effect of varicocelectomy on serum testosterone levels in infertile men with varicoceles.J Urol. 1995 Nov;154(5):1752-5 PMID: 7563339
-
Treatment of varicocele in subfertile men: The Cochrane Review--a contrary opinion.Eur Urol. 2006 Feb;49(2):258-63 PMID: 16426727
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Assessment of efficacy of varicocele repair for male subfertility: a systematic review.Lancet. 2003 May 31;361(9372):1849-52 PMID: 12788571
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