Home LiteratureArticle Details
PMID: 26579440 Published · ppublish English

Emerging role of microRNAs in lipid metabolism.

Acta pharmaceutica Sinica. B ·Vol. 5 ·No. 2 ·2015-11-20

Yang Zhihong, Cappello Tyler, Wang Li

Abstract

microRNAs (miRNAs or miRs) are small non-coding RNAs that are involved in post-transcriptional regulation of their target genes in a sequence-specific manner. Emerging evidence demonstrates that miRNAs are critical regulators of lipid synthesis, fatty acid oxidation and lipoprotein formation and secretion. Dysregulation of miRNAs disrupts gene regulatory network, leading to metabolic syndrome and its related diseases. In this review, we introduced epigenetic and transcriptional regulation of miRNAs expression. We emphasized on several representative miRNAs that are functionally involved into lipid metabolism, including miR-33/33(⁎), miR122, miR27a/b, miR378/378(⁎), miR-34a and miR-21. Understanding the function of miRNAs in lipid homeostasis may provide potential therapeutic strategies for fatty liver disease.

Keywords
ABCA1 adenosine triphosphate-binding cassette transporter A1 ABCG1 adenosine triphosphate-binding cassette transporter G1 AMPKα AMP-activated protein kinase α ATP8B1 aminophospholipid transporter class I type 8B member 1 Ago2 argonaute 2 ApoA1 apolipoprotein A1 BDL bile-duct ligation CPT1A carnitine palmitoyltransferase 1A CRAT carnitine O-acetyltransferase CYP26 cytochrome P450 family 26 CYP3A4 cytochrome P450 family 3 subfamily A polypeptide 4 ERRγ estrogen-related receptor gamma FABP7 fatty acid-binding protein 7 FASN fatty acid synthase FGF21 fibroblast growth factor 21 FGFR1 fibroblast growth factor receptor 1 FXR farnesoid X receptor GABPA GA binding protein transcription factor alpha subunit GPC6 glypican 6 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase trifunctional protein beta subunit HCC hepatocellular carcinoma HCV hepatitis C virus HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCS1 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 HNE 4-hydroxynonenal IGF1R insulin-like growth factor 1 receptor IGFBP3 insulin-like growth factor binding protein 3 INSIG1 insulin induced gene 1 LIPE lipase hormone-sensitive LNA locked nucleic acids LNPs lipid-based nanoparticles LPS lipopolysaccharide Lipid metabolism MED13 mediator complex subunit 13 MHV68 murine γ-herpesvirus 68 MTTP microsomal TG transfer protein NR1D1/REV-ERBα transcriptional repressor nuclear receptor subfamily 1 group D member 1 NRs nuclear receptors Nuclear receptors PCK1 phosphoenolpyruvate carboxykinase 1 PDCD4 programmed cell death 4 PGC-1 peroxisone proliferator-activated receptor gamma coactivator PLIN1 perilipin 1 PNA peptide nucleic acid PNPLA2 patatin-like phospholipase domain containing 2 PPARγ peroxisone proliferator-activated receptor gamma RTL1 retrotransposon-like 1 RXRα retinoid X receptor alpha SHP small heterodimer partner SIRT1 sirtuin 1 SIRT6 sirtuin 6 TG triglyceride TLR4 toll-like receptor 4 miRNAs or miRs microRNAs microRNAs pre-miRNAs precursor-miRNAs pri-miRNAs primary-miRNAs
Article Info
Journal
Acta pharmaceutica Sinica. B
Abbr.
Acta Pharm Sin B
Published
2015-11-20
Indexed
2015-11-20
Updated
2016-10-25
Language
English
Country/Region
Netherlands
NLM ID
101600560
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]