Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).

Organic & biomolecular chemistry ·第 14 卷 ·第 2 期 ·2016-07-27

Zhan Yang, Zhang Xiao-Wei, Xiong Ying, Li Bo-Liang, Nan Fa-Jun

摘要

A series of pyripyropene A-based compounds were designed and synthesized by opening the upper section of the A-ring, which significantly simplifies the structure and synthesis from commercially available starting materials. Representative compound (-)-3 exhibited potent activity against ACAT2 and greater selectivity for ACAT2 than for ACAT1.

文献信息

期刊

Organic & biomolecular chemistry

期刊简称

Org Biomol Chem

ISSN

1477-0520

DOI

10.1039/c5ob02019k

发表日期

2016-07-27

收录日期

2015-12-23

更新日期

2015-12-23

语言

英语

国家/地区

England

NLM ID

101154995

外部链接

PubMed 原文 DOI: 10.1039/c5ob02019k 查看期刊详情

分析服务

Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2).

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