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PMID: 2666863 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Association of class I major histocompatibility heavy and light chains induced by viral peptides.

Nature ·Vol. 340 ·No. 6233 ·1989-08-10 ·Pages 443-8

Townsend A, Ohlén C, Bastin J, Ljunggren HG, Foster L, Kärre K

Abstract

We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.

MeSH Terms
Animals Cell Line Cell Membrane/immunology Cell Transformation, Viral Histocompatibility Antigens Class I/genetics,immunology,isolation & purification Macromolecular Substances Mutation Nucleocapsid Proteins Nucleoproteins/immunology Orthomyxoviridae/genetics Protein Conformation RNA-Binding Proteins Viral Core Proteins Viral Proteins/immunology beta 2-Microglobulin/immunology,isolation & purification
Chemicals
Histocompatibility Antigens Class I Macromolecular Substances NP protein, Influenza A virus Nucleocapsid Proteins Nucleoproteins RNA-Binding Proteins Viral Core Proteins Viral Proteins beta 2-Microglobulin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Townsend A
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Ohlén C
Bastin J
Ljunggren H G
Foster L
Kärre K
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/340443a0
Published
1989-08-10
Pages
443-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
Corrections
CommentIn
PMID: 2392148
External Links
PubMed source DOI: 10.1038/340443a0 View journal details
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