Functional evolutionary divergence of proteolytic enzymes and their inhibitors.

Trends in biochemical sciences ·Vol. 14 ·No. 8 ·1989-08-00 ·Pages 319-24

Creighton TE, Darby NJ

Abstract

The amino acid residues of protease inhibitors that interact directly with proteases are hypervariable, suggesting recent positive evolutionary selection for functional differences between them. A similar hypervariability is apparent in some proteases, which may be co-evolving with the inhibitors.

MeSH Terms

Animals Binding Sites Biological Evolution Genes Genetic Variation Humans Peptide Hydrolases/genetics,metabolism Protease Inhibitors/metabolism Protein Conformation Selection, Genetic

Chemicals

Protease Inhibitors Peptide Hydrolases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Creighton T E

Darby N J

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(89)90159-x

Published

1989-08-00

Pages

319-24

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/0968-0004(89)90159-x View journal details

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Functional evolutionary divergence of proteolytic enzymes and their inhibitors.

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