On the location of palindromes in immunoglobulin genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 6 ·1977-06-00 ·Pages 2526-30

Wuilmart C, Urbain J, Givol D

Abstract

We present a statistical method for detection of palindromes in mRNA or DNA, starting from the protein sequence. Analysis of immunoglobulin genes by this method demonstrates that palindromic sequences are not randomly distributed. They are located at each side of the hypervariable regions in the variable (V) genes, whereas no such regular design is observed in the constant (C) genes. In addition, palindromic sequences overlap the V-C junction in all immunoglobulin classes and significant palindromes are present near residue 216 of the heavy chain, which is the end of deletions in many heavy chain diseases. The relevance of these palindromes to gene translocation and generation of diversity in antibodies is discussed.

MeSH Terms

Base Sequence DNA/metabolism Genes Genetic Code Genetic Complementation Test Genetic Variation Humans Immunoglobulins/biosynthesis Mathematics Probability RNA, Messenger/metabolism

Chemicals

Immunoglobulins RNA, Messenger DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wuilmart C

Urbain J

Givol D

References (29)

29 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.74.6.2526

Published

1977-06-00

Pages

2526-30

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC432206

Subset

External Links

PubMed source DOI: 10.1073/pnas.74.6.2526 PMC Full Text View journal details

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On the location of palindromes in immunoglobulin genes.

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