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PMID: 2680755 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources.

Genetics ·Vol. 123 ·No. 1 ·1989-09-00 ·Pages 19-28

Sonti RV, Roth JR

Abstract

Duplication-containing cells are selected when growth of Salmonella typhimurium is limited by the availability of any one of several carbon and energy sources. Under conditions of extreme starvation, growth occurs almost exclusively in the duplication-containing fraction of the population. Cells with duplications of one large segment of the chromosome are repeatedly selected regardless of which of these carbon sources limits growth. The duplicated chromosomal segment encodes the transport systems for all of these carbon sources. This duplication is not selected during growth on a carbon source for which the permease is not included within the duplication segment. This suggests that the growth advantage conferred by the duplication may be due to increased transport of the limiting carbon source. Inclusion of the permease alone is not sufficient to explain the growth advantage of the duplications, since other common duplications that include the permease are not selected.

MeSH Terms
Adaptation, Physiological Arabinose/pharmacology Carbon/metabolism Chromosome Mapping Culture Media Multigene Family Salmonella typhimurium/genetics Selection, Genetic Sorbitol/pharmacology Transduction, Genetic
Chemicals
Culture Media Sorbitol Carbon Arabinose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sonti R V
Department of Biology, University of Utah, Salt Lake City 84112.
Roth J R
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/123.1.19
Published
1989-09-00
Pages
19-28
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1203782
Subset
IM
Grants
NIGMS NIH HHS · GM 27068 · United States
External Links
PubMed source DOI: 10.1093/genetics/123.1.19 PMC Full Text View journal details
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