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PMID: 2680971 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interleukin-6 induced at mucosal surfaces by gram-negative bacterial infection.

Infection and immunity ·Vol. 57 ·No. 11 ·1989-11-00 ·Pages 3383-8

de Man P, van Kooten C, Aarden L, Engberg I, Linder H, Svanborg Edén C

Abstract

Interleukin-6 (IL-6) was produced in response to mucosal and systemic infection of mice with gram-negative bacteria. The IL-6 response was controlled by the lipopolysaccharide gene, Lps; in C3H/HeN mice (Lpsn/Lpsn), the urinary IL-6 levels increased within 30 min after challenge with Escherichia coli, but no response occurred in C3H/HeJ mice (Lpsd/Lpsd). In lipopolysaccharide-responder mice, the levels of local and systemic IL-6 were related to the degree of infection. The urinary response dominated after intravesical challenge, and the serum response dominated after intraperitoneal challenge. The results demonstrate that IL-6 is activated as part of lipopolysaccharide-induced mucosal and systemic responses to gram-negative bacterial infections.

MeSH Terms
Animals Escherichia coli Infections/genetics,microbiology,physiopathology Genes Interleukin-1/biosynthesis Interleukin-6/biosynthesis,urine Kidney/microbiology Lipopolysaccharides/pharmacology Mice Mice, Inbred C3H Mucous Membrane/immunology,microbiology Time Factors Urinary Bladder/microbiology Urinary Tract Infections/microbiology,physiopathology
Chemicals
Interleukin-1 Interleukin-6 Lipopolysaccharides
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
de Man P
Department of Clinical Immunology, University of Göteborg, Sweden.
van Kooten C
Aarden L
Engberg I
Linder H
Svanborg Edén C
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.57.11.3383-3388.1989
Published
1989-11-00
Pages
3383-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259830
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.57.11.3383-3388.1989 PMC Full Text View journal details
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