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PMID: 2682327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases.

Neurobiology of aging ·Vol. 10 ·No. 5 ·1989-00-00 ·Pages 515-33

Hefti F, Hartikka J, Knusel B

Abstract

This review summarizes the current knowledge of characterized neurotrophic factors, including nerve growth factor (NGF) which serves as paradigmatic example when studying novel molecules. Special consideration is given to the function of neurotrophic factors in the adult and aging brain. Strategies are discussed for the eventual development of pharmacological applications of these molecules in the treatment of neurodegenerative diseases.

MeSH Terms

Aging/metabolism,physiology Alzheimer Disease/drug therapy Animals Humans Nerve Growth Factors/pharmacology,physiology,therapeutic use Nervous System/drug effects,metabolism Nervous System Physiological Phenomena Parkinson Disease/drug therapy

Chemicals

Nerve Growth Factors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hefti F

Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.

Hartikka J

Knusel B

Article Info

Journal

Neurobiology of aging

Abbr.

Neurobiol Aging

ISSN

0197-4580

DOI

10.1016/0197-4580(89)90118-8

Published

1989-00-00

Pages

515-33

Language

English

Region

United States

NLM ID

8100437

Subset

Grants

NINDS NIH HHS · NS22933 · United States

External Links

PubMed source DOI: 10.1016/0197-4580(89)90118-8 View journal details

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Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases.

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