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PMID: 2686112 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Retinoids and vertebrate limb pattern formation.

Trends in genetics : TIG ·Vol. 5 ·No. 8 ·1989-08-00 ·Pages 246-51

Eichele G

Abstract

It has long been suggested that pattern formation depends in part on signalling molecules known as 'morphogens', diffusible substances that determine cell fate in a concentration-dependent way. Retinoic acid, a small hydrophobic molecule that binds to nuclear receptors, is a candidate morphogen for specifying the anteroposterior pattern of vertebrate limbs.

MeSH Terms
Animals Chick Embryo Extremities/growth & development Gene Expression Morphogenesis Signal Transduction Tretinoin/pharmacology
Chemicals
Tretinoin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Eichele G
Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/0168-9525(89)90096-6
Published
1989-08-00
Pages
246-51
Language
English
Region
England
NLM ID
8507085
Subset
IM
Grants
NICHD NIH HHS · HD 20209 · United States
External Links
PubMed source DOI: 10.1016/0168-9525(89)90096-6 View journal details
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