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PMID: 2705997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation.

The Biochemical journal ·Vol. 258 ·No. 2 ·1989-03-01 ·Pages 529-33

Holness MJ, Sugden MC

Abstract

We investigated the temporal relationship between hepatic glycogen depletion and cardiac and hepatic PDH (pyruvate dehydrogenase complex) activities during the acute phase of starvation. There was a striking correlation between the decline in hepatic glycogen and PDH inactivation during the first 10 h of starvation. Re-feeding after 6 h starvation was associated with complete re-activation of PDH in liver and re-activation to approx. 75% of the fed value in heart, whereas in rats previously starved for 24-48 h re-activation was delayed in liver and diminished in heart. The results are discussed with reference to the fate of dietary carbohydrate after re-feeding.

MeSH Terms
Animals Female Food Liver/enzymology Liver Glycogen/analysis,deficiency Myocardium/enzymology Pyruvate Dehydrogenase Complex/metabolism Rats Rats, Inbred Strains Starvation/metabolism Time Factors
Chemicals
Liver Glycogen Pyruvate Dehydrogenase Complex
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Holness M J
Department of Chemical Pathology, London Hospital Medical College, U.K.
Sugden M C
References (28)
28 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2580529
Published
1989-03-01
Pages
529-33
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1138393
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2580529 PMC Full Text View journal details
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