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PMID: 270749 Published · ppublish English Journal Article

Chemical characterization of murine Ia alloantigens determined by the i-E/i-C subregions of the H-2 complex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 11 ·1977-11-00 ·Pages 5131-4

Silver J, Russell WA, Reis BL, Frelinger JA

Abstract

Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.

MeSH Terms
Amino Acid Sequence Animals Chemical Phenomena Chemistry H-2 Antigens Mice/immunology Molecular Weight Spleen/immunology
Chemicals
H-2 Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Silver J
Russell W A
Reis B L
Frelinger J A
References (34)
34 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.11.5131
Published
1977-11-00
Pages
5131-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432114
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.11.5131 PMC Full Text View journal details
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