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PMID: 27149507 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Transient overexpression of exogenous APOBEC3A causes C-to-U RNA editing of thousands of genes.

RNA biology ·Vol. 14 ·No. 5 ·2017-00-04 ·Pages 603-610

Sharma S, Patnaik SK, Kemer Z, Baysal BE

Abstract

APOBEC3A cytidine deaminase induces site-specific C-to-U RNA editing of hundreds of genes in monocytes exposed to hypoxia and/or interferons and in pro-inflammatory macrophages. To examine the impact of APOBEC3A overexpression, we transiently expressed APOBEC3A in HEK293T cell line and performed RNA sequencing. APOBEC3A overexpression induces C-to-U editing at more than 4,200 sites in transcripts of 3,078 genes resulting in protein recoding of 1,110 genes. We validate recoding RNA editing of genes associated with breast cancer, hematologic neoplasms, amyotrophic lateral sclerosis, Alzheimer disease and primary pulmonary hypertension. These results highlight the fundamental impact of APOBEC3A overexpression on human transcriptome by widespread RNA editing.

Keywords
Cytidine deaminase RNA editing RNA seq disease genes epitranscriptomics
MeSH Terms
Base Sequence Cytidine Deaminase/genetics,metabolism Disease/genetics HEK293 Cells Humans Hypoxia/metabolism Interferons/metabolism Macrophages/metabolism Monocytes/metabolism Proteins/genetics,metabolism RNA/genetics,metabolism RNA Editing Transcriptome
Chemicals
Proteins RNA Interferons APOBEC3A protein, human Cytidine Deaminase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sharma Shraddha
a Department of Pathology , Roswell Park Cancer Institute , Buffalo , NY , USA.
Patnaik Santosh K
b Department of Thoracic Surgery , Roswell Park Cancer Institute , Buffalo , NY , USA.
Kemer Zeynep
a Department of Pathology , Roswell Park Cancer Institute , Buffalo , NY , USA.
Baysal Bora E
a Department of Pathology , Roswell Park Cancer Institute , Buffalo , NY , USA.
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Article Info
Journal
RNA biology
Abbr.
RNA Biol
ISSN
1555-8584
Published
2017-00-04
Epub
2016-00-05
Pages
603-610
Language
English
Region
United States
NLM ID
101235328
PMCID
PMC5449087
Subset
IM
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