Abstract
APOBEC3A cytidine deaminase induces site-specific C-to-U RNA editing of hundreds of genes in monocytes exposed to hypoxia and/or interferons and in pro-inflammatory macrophages. To examine the impact of APOBEC3A overexpression, we transiently expressed APOBEC3A in HEK293T cell line and performed RNA sequencing. APOBEC3A overexpression induces C-to-U editing at more than 4,200 sites in transcripts of 3,078 genes resulting in protein recoding of 1,110 genes. We validate recoding RNA editing of genes associated with breast cancer, hematologic neoplasms, amyotrophic lateral sclerosis, Alzheimer disease and primary pulmonary hypertension. These results highlight the fundamental impact of APOBEC3A overexpression on human transcriptome by widespread RNA editing.
Keywords
Cytidine deaminase
RNA editing
RNA seq
disease genes
epitranscriptomics
MeSH Terms
Base Sequence
Cytidine Deaminase/genetics,metabolism
Disease/genetics
HEK293 Cells
Humans
Hypoxia/metabolism
Interferons/metabolism
Macrophages/metabolism
Monocytes/metabolism
Proteins/genetics,metabolism
RNA/genetics,metabolism
RNA Editing
Transcriptome
Chemicals
Proteins
RNA
Interferons
APOBEC3A protein, human
Cytidine Deaminase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sharma Shraddha
a Department of Pathology , Roswell Park Cancer Institute , Buffalo , NY , USA.
Patnaik Santosh K
b Department of Thoracic Surgery , Roswell Park Cancer Institute , Buffalo , NY , USA.
Kemer Zeynep
a Department of Pathology , Roswell Park Cancer Institute , Buffalo , NY , USA.
Baysal Bora E
a Department of Pathology , Roswell Park Cancer Institute , Buffalo , NY , USA.
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