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PMID: 2720084 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Current injection into a two-dimensional anisotropic bidomain.

Biophysical journal ·Vol. 55 ·No. 5 ·1989-05-00 ·Pages 987-99

Sepulveda NG, Roth BJ, Wikswo JP

Abstract

A two-dimensional sheet of anisotropic cardiac tissue is represented with the bidomain model, and the finite element method is used to solve the bidomain equations. When the anisotropy ratios of the intracellular and extracellular spaces are not equal, the injection of current into the tissue induces a transmembrane potential that has a complicated spatial dependence, including adjacent regions of depolarized and hyperpolarized tissue. This behavior may have important implications for the electrical stimulation of cardiac tissue and for defibrillation.

MeSH Terms
Animals Electric Conductivity Electric Stimulation Heart/physiology Mathematics Membrane Potentials Models, Cardiovascular
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sepulveda N G
Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235.
Roth B J
Wikswo J P
References (13)
13 references, click to expand
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(89)82897-8
Published
1989-05-00
Pages
987-99
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1330535
Subset
IM
Grants
NHLBI NIH HHS · HL36724 · United States
NINDS NIH HHS · NS19794 · United States
NINDS NIH HHS · NS24751 · United States
External Links
PubMed source DOI: 10.1016/S0006-3495(89)82897-8 PMC Full Text View journal details
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