A Ribosomal Perspective on Proteostasis and Aging.

Cell metabolism ·Vol. 23 ·No. 6 ·2016-06-14 ·Pages 1004-1012

Steffen KK, Dillin A

Abstract

As the first and most direct process influencing the proteostasis capacity of a cell, regulation of translation influences lifespan across taxa. Here we highlight some of the newly discovered means by which translational regulation affects cellular proteostasis, with a focus on mechanisms that may ultimately impinge upon the aging process.

MeSH Terms

Aging/metabolism Animals Humans Models, Biological Protein Biosynthesis Proteins/metabolism Ribosomes/metabolism Stress, Physiological

Chemicals

Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Steffen Kristan K

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Dillin Andrew

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; The Glenn Center for Aging Research, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: [email protected].

Article Info

Journal

Cell metabolism

Abbr.

Cell Metab

ISSN

1932-7420

DOI

10.1016/j.cmet.2016.05.013

[email protected]

Published

2016-06-14

Pages

1004-1012

Language

English

Region

United States

NLM ID

101233170

Subset

External Links

PubMed source DOI: 10.1016/j.cmet.2016.05.013 View journal details

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