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PMID: 27418283 Published · ppublish English Journal Article Review

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy.

BMB reports ·Vol. 49 ·No. 8 ·2016-08-00 ·Pages 424-30

Lee YK, Lee JA

Abstract

Autophagy, an evolutionarily conserved cellular degradation pathway of the lysosome, is associated with many physiological and pathological processes. The hallmark of autophagy is the formation of the autophagosome that engulfs and degrades cytosolic components via its fusion with the lysosome, in either a selective or a non-selective manner. Autophagy is tightly regulated by proteins encoded by autophagy-related (atg) genes. Among these proteins, ATG8/ LC3 is essential for autophagosome biogenesis/maturation and it also functions as an adaptor protein for selective autophagy. In mammalian cells, several homologs of yeast Atg8 such as MAP1LC3, GABARAP, and GABARAPL 1/2 have been identified. However, the biological relevance of this gene diversity in higher eukaryotes, and their specific roles, are largely unknown. In this review, we describe the mammalian ATG8/LC3 family and discuss recent advancements in understanding their roles in the autophagic process. [BMB Reports 2016; 49(8): 424-430].

MeSH Terms
Animals Autophagy Autophagy-Related Protein 8 Family/chemistry,metabolism Humans Mammals/metabolism Microtubule-Associated Proteins/chemistry,metabolism Models, Biological Protein Domains
Chemicals
Autophagy-Related Protein 8 Family Microtubule-Associated Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lee You-Kyung
Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon 34054, Korea.
Lee Jin-A
Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon 34054, Korea.
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Article Info
Journal
BMB reports
Abbr.
BMB Rep
ISSN
1976-670X
DOI
10.5483/bmbrep.2016.49.8.081
Published
2016-08-00
Pages
424-30
Language
English
Region
Korea (South)
NLM ID
101465334
PMCID
PMC5070729
Subset
IM
External Links
PubMed source DOI: 10.5483/bmbrep.2016.49.8.081 PMC Full Text View journal details
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