EFFECT OF CYTOKINE SIGNALING 3 GENE POLYMORPHISMS IN CHILDHOOD OBESITY.

Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, metabolic syndrome and type 2 diabetes in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children with and without metabolic syndrome and compared the results with that of controls.,148 obese and 63 age and sex matched control children were enrolled in the study. Genotyping procedure was carried out by PCR- sequencing protocol Results:The frequency of rs2280148 polymorphism was significantly higher in obese children with metabolic syndrome than that of the control group, whereas the frequency of rs8064821 polymorphism was significantly higher in obese children with metabolic syndrome than that of obese children without metabolic syndrome.,The significant association of certain SOCS3 polymorphisms with obesity parameters in both metabolic syndrome and metabolic syndrome related insulin resistance, hypertension, and fatty liver suggest that polymorphisms in this gene may play a role in the pathogenesis of metabolic syndrome and also that they can be potentially used as a marker for attenuated or aggressive disease.