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PMID: 2784569 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 7 ·1989-04-00 ·Pages 2361-4

Storkus WJ, Alexander J, Payne JA, Dawson JR, Cresswell P

Abstract

A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this protection did not extend to cytotoxicity mediated by interleukin 2-stimulated human NK effector cells.

MeSH Terms
B-Lymphocytes/immunology Cell Line Cells, Cultured Cloning, Molecular Genes, MHC Class I Humans Killer Cells, Natural/immunology Mutation Reference Values Transfection
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Storkus W J
Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
Alexander J
Payne J A
Dawson J R
Cresswell P
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.7.2361
Published
1989-04-00
Pages
2361-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286912
Subset
IM
Grants
NIAID NIH HHS · AI15775 · United States
NCI NIH HHS · CA09058 · United States
NCI NIH HHS · CA42890 · United States
External Links
PubMed source DOI: 10.1073/pnas.86.7.2361 PMC Full Text View journal details
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