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PMID: 2784661 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunological and immunohistochemical analysis of rheumatoid nodules.

Annals of the rheumatic diseases ·Vol. 48 ·No. 3 ·1989-03-00 ·Pages 220-6

Miyasaka N, Sato K, Yamamoto K, Goto M, Nishioka K

Abstract

An attempt was made to examine the pathophysiology of the rheumatoid nodule. Significant amounts of interleukin 1-like activity and prostaglandin E2 were detected in the supernatants from in vitro organ cultures of rheumatoid nodule tissue. When fresh (but not old) rheumatoid nodules were minced and cultured in vitro prominent outgrowths of cells were observed. These cells expressed both HLA-DR and CD14 antigens but lacked conventional differentiation antigens for T cells and B cells, suggesting that they are of monocyte-macrophage origin. These data suggest that interleukin 1 and prostaglandin E2 may be deeply involved in the formation of rheumatoid nodules.

MeSH Terms
Adult Antigens, Surface/analysis Cells, Cultured Dinoprostone/analysis Female Humans Interleukin-1/analysis Male Middle Aged Rheumatoid Nodule/immunology,metabolism
Chemicals
Antigens, Surface Interleukin-1 Dinoprostone
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Miyasaka N
Division of Clinical Immunology, Tokyo Women's Medical College, Japan.
Sato K
Yamamoto K
Goto M
Nishioka K
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22 references, click to expand
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.48.3.220
Published
1989-03-00
Pages
220-6
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1003725
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.48.3.220 PMC Full Text View journal details
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