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PMID: 2785522 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis.

The Journal of cell biology ·Vol. 108 ·No. 5 ·1989-05-00 ·Pages 1935-43

Gresham HD, Goodwin JL, Allen PM, Anderson DC, Brown EJ

Abstract

Human neutrophils (PMN) express a heterodimeric receptor that has ligand binding specificity for the Arg-Gly-Asp (RGD) sequence within many adhesive proteins. A monoclonal antibody, B6H12, which binds to this receptor, inhibits both RGD-mediated ligand binding and stimulation of IgG-mediated phagocytosis by fibronectin, fibrinogen, vitronectin, von Willebrand's factor, and collagen type IV. By several criteria this receptor is neither a known very late antigen, a known cytoadhesin (gp IIb/IIIa-vitronectin receptor), nor a member of the LFA-1, Mac-1, p150,95 group of integrin receptors. Ligand binding via this receptor is rapidly inactivated by products of the myeloperoxidase-hydrogen peroxide-halide system of PMN. We conclude that this receptor, for which we propose the name leukocyte response integrin, is a signal-transducing molecule on PMN which may have a significant early role in modulation of PMN function at inflammatory sites.

MeSH Terms
Amino Acid Sequence Blood Platelets/immunology Catalase/pharmacology Cell Membrane/immunology Female Humans In Vitro Techniques Integrins Kinetics Membrane Glycoproteins/physiology Molecular Sequence Data Neutrophils/drug effects,immunology,physiology Oligopeptides/pharmacology Phagocytosis/drug effects Placenta/immunology Pregnancy Receptors, Immunologic/physiology
Chemicals
Integrins Membrane Glycoproteins Oligopeptides Receptors, Immunologic arginyl-glycyl-aspartic acid Catalase
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Gresham H D
Department of Medicine, Washington University, St. Louis, Missouri 63110.
Goodwin J L
Allen P M
Anderson D C
Brown E J
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.108.5.1935
Published
1989-05-00
Pages
1935-43
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2115539
Subset
IM
Grants
NIAID NIH HHS · AI-23790 · United States
NIGMS NIH HHS · GM-38330 · United States
External Links
PubMed source DOI: 10.1083/jcb.108.5.1935 PMC Full Text View journal details
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