The leukocyte integrins.

During the 1980s, various laboratories identified a rare type of patient suffering from recurrent bacterial infections whose neutrophils showed reduced spreading on surfaces. Such leukocyte adhesion deficient (LAD) patients were shown to lack a trio of molecules named either LFA-1, CR3/Mac-1/Mo1, p150,95/CR4 or CD11, CD18 or the leukocyte integrin family. In September 1988, the first meeting exclusively devoted to this topic was held.