Comparison of the quality of life of early and advanced stage ovarian cancer survivors.

5528 Background: No direct quality of life (QOL) comparisons have been performed based on ovarian cancer staging. The objective of this study was to compare the long-term adjustment and QOL of both early and advanced stage ovarian cancer survivors (OCS).,Early and advanced OCS were identified from patient logs. All patients were >3 years from diagnosis and had no evidence of recurrent cancer. Patients were interviewed by phone or in clinic, and the following surveys were administered: EORTC QLQ-C30 (EORTC) and QLQ-OV28 (OV-28), MHI-17, CALGB sexual functioning, FACT Fatigue, Beck's Hopelessness, Fear of Recurrence (FOR), PCL-C post-traumatic stress disorder (PTSD), Unmet Needs, FACT-Spirituality (FACT-Sp), complementary therapy use, and MOS Social Support (MOS). Overall QOL and long-term physical, mental, and sexual effects were compared between the early and advanced stage groups.,58 early stage and 42 advanced pts were interviewed. Except for social functioning (EORTC-social functioning, p< .05;), there were no differences in physical symptoms, functioning and psychological state between the two groups. Anxiety when getting CA125 tested was reported by 59% of early stage and 64% of advanced stage survivors. The percent of survivors scoring at the norm or greater on the MHI Index was 71% for early stage survivors and 64% for advanced stage survivors. The following variables did not differ significantly between the two groups: overall quality of life (EORTC), fatigue (FACT), hopelessness (BECK), spirituality (FACT-Sp), social support (MOS), unmet needs and use of complementary therapy. Psychological assessment revealed that 26% of both the early and advanced OCS had scores indicative of PTSD (PCL-C). Decreased sexual interest attributed to cancer was reported by 54% of early stage and 31% of advanced stage survivors, while 40.5% early stage and 46% advanced stage survivors reported decreased sexual activity attributed to cancer.,Long-term QOL and adjustment appear to be independent of initial stage. PTSD and sexual disinterest are important issues for OCS of both early and advanced stage patients in remission. No significant financial relationships to disclose.