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PMID: 2797207 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Muscle-specific gene expression controlled by a regulatory element lacking a MyoD1-binding site.

Nature ·Vol. 341 ·No. 6244 ·1989-10-26 ·Pages 716-20

Baldwin TJ, Burden SJ

Abstract

Muscle-specific expression of the gene encoding the delta subunit of the acetylcholine receptor is controlled by a 54-base-pair region that does not contain a binding site for MyoD1, a protein involved in activation of the myogenic program. A MyoD1-binding site is present in the proximal promoter region of the gene encoding the delta-subunit, but is neither sufficient nor necessary for muscle-specific expression in transfected muscle cells.

MeSH Terms

Animals Base Sequence DNA-Binding Proteins/metabolism Electrophoresis Gene Expression Regulation Mice Molecular Sequence Data Muscles/cytology,metabolism MyoD Protein Nuclear Proteins/metabolism Phosphoproteins/metabolism Receptors, Cholinergic/genetics Regulatory Sequences, Nucleic Acid Restriction Mapping Transcription, Genetic Transfection

Chemicals

DNA-Binding Proteins MyoD Protein MyoD1 myogenic differentiation protein Nuclear Proteins Phosphoproteins Receptors, Cholinergic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Baldwin T J

Biology Department, Massachusetts Institute of Technology, Cambridge 02139.

Burden S J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/341716a0

Published

1989-10-26

Pages

716-20

Language

English

Region

England

NLM ID

0410462

Subset

Grants

NINDS NIH HHS · R01 NS021579-14 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1038/341716a0 View journal details

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Muscle-specific gene expression controlled by a regulatory element lacking a MyoD1-binding site.

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