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PMID: 279903 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Hatching in the sea urchin Lytechinus pictus is accompanied by a shift in histone H4 gene activity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 9 ·1978-09-00 ·Pages 4135-9

Grunstein M

Abstract

There is a distinct shift in histone mRNA synthesis at approximately 11--12 hr of sea urchin emhryogenesis, coincident with embryonic hatching. The synthesis of the blastula type (early) histone mRNAs gradually ceases at this stage and a new class of posthatching (late) histone mRNAs is produced. Briefly labeled early and late mRNAs were isolated and identified by means of RNA-DNA hybridization to different cloned histone genes. The late histone HI mRNA is approximately 40 nucleotides longer than the early HI mRNA. The H3, H2A, H2B, and H4 late mRNAs are 15--40 nucleotides shorter than their early counterparts. We present sequence evidence to show that the genes coding for the late H4 mRNA are a separate class from those that code for the early histone H4 message.

MeSH Terms
Animals Base Sequence Genes Histones/genetics RNA, Messenger/genetics Sea Urchins/embryology,genetics
Chemicals
Histones RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Grunstein M
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32 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.9.4135
Published
1978-09-00
Pages
4135-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336066
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.9.4135 PMC Full Text View journal details
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