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PMID: 279928 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Amplification of DNA sequences during chicken cartilage and neural retina differentiation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 9 ·1978-09-00 ·Pages 4451-4

Strom CM, Moscona M, Dorfman A

Abstract

[3H]BrdUrd-substituted DNA probes were prepared from organ cultures of differentiating chicken neural retina and cell cultures of stage 24 chicken limb buds. Reassociation reactions using the neural retina probe demonstrated amplification of DNA sequences during differentiation of neural retina. This probe also contained sequences present in greater numbers in heart DNA than in DNA from undifferentiated neural retina. Reassociation reactions of both differentiated cartilage and differentiated neural retina DNA with both the neural retina probe and the cartilage probe demonstrated that at least part of the amplified sequences are tissue specific.

MeSH Terms
Animals Base Sequence Bromodeoxyuridine/pharmacology Cartilage/cytology Cell Differentiation/drug effects DNA/metabolism Nucleic Acid Renaturation Retina/cytology,embryology
Chemicals
DNA Bromodeoxyuridine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Strom C M
Moscona M
Dorfman A
References (11)
11 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.9.4451
Published
1978-09-00
Pages
4451-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336133
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.9.4451 PMC Full Text View journal details
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