Home LiteratureArticle Details
PMID: 2806416 Published · ppublish English Journal Article

Immunosuppression and mycobacteria other than Mycobacterium tuberculosis: results from patients with and without HIV infection.

Epidemiology and infection ·Vol. 103 ·No. 2 ·1989-10-00 ·Pages 293-300

Peters M, Schürmann D, Mayr AC, Heterzer R, Pohle HD, Ruf B

Abstract

Infections caused by mycobacteria other than Mycobacterium tuberculosis (MOTT) have often been described as common in AIDS patients. To evaluate whether infections with MOTT are specific for HIV related immunosuppression or are also frequent in patients with immunosuppression of different aetiology, data on the frequency of isolation from immunosuppressed patients with HIV infection are important. Blood, stool and urine specimens from 134 patients with non-HIV related immunosuppression, and from 55 immunocompetent subjects were examined for mycobacteria. MOTT have been isolated from one immunocompetent person but from none of the immunosuppressed patients. Since in AIDS patients an initial colonization of the gastrointestinal tract (GI-tract) with MOTT is common, GI-tract biopsy specimens from an additional 80 patients were examined microscopically and histologically for mycobacteria. Mycobacteria were not isolated from these specimens. In the same period of time 72 AIDS patients have been examined; 7 (10%) had infections with M. tuberculosis whereas MOTT have been isolated from 16 (22%) of these patients. Mycobacteria have been found only rarely in immunocompetent patients and have not been isolated from patients with non-HIV related immunosuppression. The isolation of MOTT is highly correlated with an HIV-related immunosuppression.

MeSH Terms
Adult Colonoscopy Female Gastroscopy HIV Infections/complications,immunology Heart Transplantation/immunology Humans Immune Tolerance Immunosuppression Therapy Male Middle Aged Mycobacterium Infections/complications Mycobacterium Infections, Nontuberculous/complications,immunology Neoplasms/complications,immunology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Peters M
II. Department of Internal Medicine Rudolf Virchow University Hospital Wedding, FRG.
Schürmann D
Mayr A C
Heterzer R
Pohle H D
Ruf B
References (31)
31 references, click to expand
  1. Bacteremia due to Mycobacterium avium-intracellulare in the acquired immunodeficiency syndrome.
    Ann Intern Med. 1983 Dec;99(6):782-5 PMID: 6359997
  2. Isolation of "atypical" mycobacteria from healthy persons.
    Am Rev Respir Dis. 1959 Nov;80:747-9 PMID: 13819428
  3. Pulmonary complications of the acquired immunodeficiency syndrome. Report of a National Heart, Lung, and Blood Institute workshop.
    N Engl J Med. 1984 Jun 21;310(25):1682-8 PMID: 6328301
  4. Tuberculosis, atypical mycobacteriosis, and the acquired immunodeficiency syndrome among Haitian and non-Haitian patients in south Florida.
    Ann Intern Med. 1984 Nov;101(5):641-5 PMID: 6333198
  5. Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: concepts regarding acquisition and pathogenesis.
    J Infect Dis. 1985 Jan;151(1):179-81 PMID: 3965590
  6. Disseminated infection with Mycobacterium avium-intracellulare. A report of 13 cases and a review of the literature.
    Medicine (Baltimore). 1985 Jan;64(1):36-48 PMID: 3880852
  7. Infections caused by Mycobacterium avium complex in immunocompromised patients: diagnosis by blood culture and fecal examination, antimicrobial susceptibility tests, and morphological and seroagglutination characteristics.
    J Clin Microbiol. 1985 Feb;21(2):168-73 PMID: 3972985
  8. Humoral response to disseminated infection by Mycobacterium avium-Mycobacterium intracellulare in acquired immunodeficiency syndrome and hairy cell leukemia.
    J Infect Dis. 1985 Mar;151(3):523-7 PMID: 3919112
  9. [Diagnostic and therapeutic progress in nontuberculous mycobacterioses].
    Prax Klin Pneumol. 1985 Feb;39(2):43-9 PMID: 3983077
  10. Gastrointestinal manifestations of the acquired immunodeficiency syndrome: a review of 22 cases.
    Am J Gastroenterol. 1985 Oct;80(10):774-8 PMID: 4041133
  11. Treatment of infections in patients with the acquired immunodeficiency syndrome.
    Ann Intern Med. 1985 Nov;103(5):738-43 PMID: 2996410
  12. Use of lysis-centrifugation (isolator) and radiometric (BACTEC) blood culture systems for the detection of mycobacteremia.
    J Clin Microbiol. 1985 Oct;22(4):543-6 PMID: 3908468
  13. Tuberculin testing for persons with positive serologic studies for HTLV-III.
    N Engl J Med. 1986 Feb 13;314(7):447 PMID: 3456078
  14. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome.
    Ann Intern Med. 1986 Aug;105(2):184-8 PMID: 3729201
  15. Mycobacterium avium-complex infections and development of the acquired immunodeficiency syndrome: casual opportunist or causal cofactor?
    Int J Lepr Other Mycobact Dis. 1986 Sep;54(3):458-74 PMID: 2943845
  16. Laboratory diagnosis of mycobacterial infections in patients with acquired immunodeficiency syndrome.
    J Clin Microbiol. 1986 Nov;24(5):708-11 PMID: 3095369
  17. Opportunistic mycobacterial infections.
    Adv Exp Med Biol. 1986;202:73-82 PMID: 3788698
  18. Mycobacterial infections in AIDS patients, with an emphasis on the Mycobacterium avium complex.
    Rev Infect Dis. 1986 Nov-Dec;8(6):1024-33 PMID: 3541122
  19. Mycobacterium avium-M. intracellulare isolates from patients with or without acquired immunodeficiency syndrome.
    Antimicrob Agents Chemother. 1986 Dec;30(6):955-7 PMID: 3813519
  20. Serologic identification and classification of the atypical mycobacteria by their agglutination.
    Am Rev Respir Dis. 1965 Dec;92(6):85-93 PMID: 5843844
  21. An atlas of sensitivity to tuberculin, PPD-B, and histoplasmin in the United States.
    Am Rev Respir Dis. 1969 Apr;99(4):Suppl:1-132 PMID: 5767603
  22. Mycobacteriosis in patients with malignant disease.
    Arch Intern Med. 1976 Jan;136(1):67-70 PMID: 1247337
  23. Sources of Mycobacterium avium complex infection resulting in human diseases.
    Am Rev Respir Dis. 1977 Dec;116(6):1057-64 PMID: 931182
  24. A comparative study of tuberculous and other mycobacterial infections and their associations with malignancy.
    Am Rev Respir Dis. 1978 Jan;117(1):39-45 PMID: 619723
  25. A demographic study of disease due to Mycobacterium kansasii or M intracellulare-avium in Texas.
    Chest. 1979 Feb;75(2):120-5 PMID: 421546
  26. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.
    N Engl J Med. 1981 Dec 10;305(24):1425-31 PMID: 6272109
  27. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction.
    N Engl J Med. 1981 Dec 10;305(24):1431-8 PMID: 6975437
  28. The prevalence of tuberculosis and drug resistance among Haitians.
    N Engl J Med. 1982 Jul 15;307(3):162-5 PMID: 6806657
  29. Mycobacterium avium complex infection.
    J Infect Dis. 1988 May;157(5):863-7 PMID: 3283260
  30. [Mycobacterioses in AIDS. Autopsy and clinical findings].
    Pathologe. 1988 Jul;9(4):218-27 PMID: 3145496
  31. NIH conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations.
    Ann Intern Med. 1984 Jan;100(1):92-106 PMID: 6318629
Article Info
Journal
Epidemiology and infection
Abbr.
Epidemiol Infect
ISSN
0950-2688
DOI
10.1017/s095026880003065x
Published
1989-10-00
Pages
293-300
Language
English
Region
England
NLM ID
8703737
PMCID
PMC2249508
Subset
IM
External Links
PubMed source DOI: 10.1017/s095026880003065x PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2