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PMID: 281705 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 11 ·1978-11-00 ·Pages 5565-9

Solter D, Knowles BB

Abstract

A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific antigen (SSEA-1) is first detected on blastomeres of 8-cell stage embryos. Trophectodermal cells are transitorily positive; however, each cell in the inner cell mass eventually expresses this antigen.

MeSH Terms
Animals Antibodies, Neoplasm Antigen-Antibody Reactions Antigens, Neoplasm Cell Line Complement System Proteins Embryo Implantation Embryo, Mammalian Female Mice Pregnancy Teratoma
Chemicals
Antibodies, Neoplasm Antigens, Neoplasm Complement System Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Solter D
Knowles B B
References (21)
21 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.11.5565
Published
1978-11-00
Pages
5565-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC393007
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.11.5565 PMC Full Text View journal details
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