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PMID: 2825132 Published · ppublish English Comparative Study Journal Article

Unusual features of CpG-rich (HTF) islands in the human alpha globin complex: association with non-functional pseudogenes and presence within the 3' portion of the zeta gene.

Nucleic acids research ·Vol. 15 ·No. 22 ·1987-11-25 ·Pages 9215-25

Fischel-Ghodsian N, Nicholls RD, Higgs DR

Abstract

We have characterised a cluster of CpG rich (HTF) islands in the alpha-globin complex and report here two unusual features: The human embryonic zeta 2-globin gene is associated with an HTF island within its 3' portion rather than at the 5' end. Furthermore at least two non-functional pseudogenes within the cluster (psi zeta 1 and psi alpha 2) are associated with CpG rich islands.

MeSH Terms
Animals Base Sequence Cytidine Monophosphate/analogs & derivatives Cytosine DNA Restriction Enzymes Dinucleoside Phosphates Genes Globins/genetics Guanine Guanosine/analogs & derivatives Humans Pseudogenes Species Specificity
Chemicals
Dinucleoside Phosphates Guanosine cytidylyl-3'-5'-guanosine Guanine Cytosine Globins DNA Restriction Enzymes Cytidine Monophosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fischel-Ghodsian N
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
Nicholls R D
Higgs D R
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/15.22.9215
Published
1987-11-25
Pages
9215-25
Language
English
Region
England
NLM ID
0411011
PMCID
PMC306463
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/15.22.9215 PMC Full Text View journal details
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