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PMID: 2828027 Published · ppublish English Journal Article

Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.

The EMBO journal ·Vol. 6 ·No. 11 ·1987-11-00 ·Pages 3379-84

Shida H, Tochikura T, Sato T, Konno T, Hirayoshi K, Seki M, Ito Y, Hatanaka M, Hinuma Y, Sugimoto M

Abstract

The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.

MeSH Terms
Animals Antigens, Viral/analysis,genetics Cell Line Deltaretrovirus/genetics Genes Genes, Viral Genetic Vectors Plasmids Promoter Regions, Genetic Rabbits Recombination, Genetic Vaccinia virus/genetics Viral Envelope Proteins/genetics
Chemicals
Antigens, Viral Viral Envelope Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Shida H
Institute for Virus Research, Kyoto University, Japan.
Tochikura T
Sato T
Konno T
Hirayoshi K
Seki M
Ito Y
Hatanaka M
Hinuma Y
Sugimoto M
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1987-11-00
Pages
3379-84
Language
English
Region
England
NLM ID
8208664
PMCID
PMC553794
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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