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PMID: 28299908 Published · ppublish English Journal Article

The DrugAge database of aging-related drugs.

Aging cell ·Vol. 16 ·No. 3 ·2017-00-00 ·Pages 594-597

Barardo D, Thornton D, Thoppil H, Walsh M, Sharifi S, Ferreira S, Anžič A, Fernandes M, Monteiro P, Grum T, Cordeiro R, De-Souza EA, Budovsky A, Araujo N, Gruber J, Petrascheck M, Fraifeld VE, Zhavoronkov A, Moskalev A, de Magalhães JP

Abstract

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds. At the time of writing, DrugAge contains 1316 entries featuring 418 different compounds from studies across 27 model organisms, including worms, flies, yeast and mice. Data were manually curated from 324 publications. Using drug-gene interaction data, we also performed a functional enrichment analysis of targets of lifespan-extending drugs. Enriched terms include various functional categories related to glutathione and antioxidant activity, ion transport and metabolic processes. In addition, we found a modest but significant overlap between targets of lifespan-extending drugs and known aging-related genes, suggesting that some but not most aging-related pathways have been targeted pharmacologically in longevity studies. DrugAge is freely available online for the scientific community and will be an important resource for biogerontologists.

Keywords
bioinformatics compound functional genomics lifespan longevity pharmacology
MeSH Terms
Aging/drug effects,genetics,metabolism Animals Antioxidants/chemistry,pharmacology Caenorhabditis elegans/drug effects,genetics,growth & development,metabolism Computational Biology/methods Databases, Pharmaceutical Drosophila melanogaster/drug effects,genetics,growth & development,metabolism Geriatrics/methods Humans Membrane Transport Modulators/chemistry,pharmacology Metabolic Networks and Pathways/drug effects Mice Saccharomyces cerevisiae/drug effects,genetics,growth & development,metabolism User-Computer Interface
Chemicals
Antioxidants Membrane Transport Modulators
Authors & Affiliations
20 authors, click to expand affiliations / ORCID
Barardo Diogo
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Thornton Daniel
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Thoppil Harikrishnan
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK. | Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham (Amrita University), Coimbatore, India.
Walsh Michael
Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
Sharifi Samim
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Ferreira Susana
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Anžič Andreja
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Fernandes Maria
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Monteiro Patrick
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Grum Tjaša
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Cordeiro Rui
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
De-Souza Evandro Araújo
Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
Budovsky Arie
The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel. | Judea Regional Research & Development Center, Carmel, 90404, Israel.
Araujo Natali
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Gruber Jan
Department of Science, Yale- NUS College, Singapore City, 138527, Singapore. | Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, 117597, Singapore.
Petrascheck Michael
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
Fraifeld Vadim E
The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Zhavoronkov Alexander
Pharmaceutical Artificial Intelligence Research Division, Emerging Technology Centers, Insilico Medicine, Inc, Johns Hopkins University at Eastern, B301, 1101 33rd Street, Baltimore, MD, 21218, USA. | The Biogerontology Research Foundation, Oxford, UK.
Moskalev Alexey
Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia. | Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia. | Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia.
de Magalhães João Pedro
Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK. | The Biogerontology Research Foundation, Oxford, UK.
References (6)
6 references, click to expand
  1. Genome-environment interactions that modulate aging: powerful targets for drug discovery.
    Pharmacol Rev. 2012 Jan;64(1):88-101 PMID: 22090473
  2. DGIdb 2.0: mining clinically relevant drug-gene interactions.
    Nucleic Acids Res. 2016 Jan 4;44(D1):D1036-44 PMID: 26531824
  3. Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.
    Aging Cell. 2016 Jun;15(3):407-15 PMID: 26970234
  4. Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing.
    Nucleic Acids Res. 2013 Jan;41(Database issue):D1027-33 PMID: 23193293
  5. AgeFactDB--the JenAge Ageing Factor Database--towards data integration in ageing research.
    Nucleic Acids Res. 2014 Jan;42(Database issue):D892-6 PMID: 24217911
  6. Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease.
    Aging (Albany NY). 2015 Sep;7(9):616-28 PMID: 26342919
Article Info
Journal
Aging cell
Abbr.
Aging Cell
ISSN
1474-9726
DOI
10.1111/acel.12585
Published
2017-00-00
Epub
2017-00-16
Pages
594-597
Language
English
Region
England
NLM ID
101130839
PMCID
PMC5418190
Subset
IM
Grants
Wellcome Trust · 104978/Z/14/Z · United Kingdom
External Links
PubMed source DOI: 10.1111/acel.12585 PMC Full Text View journal details
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