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PMID: 2831073 Published · ppublish English Comparative Study Journal Article Review

Platelets as a model for neurones?

Experientia ·Vol. 44 ·No. 2 ·1988-02-15 ·Pages 115-26

Da Prada M, Cesura AM, Launay JM, Richards JG

Abstract

The multiple biochemical and pharmacological similarities existing between blood platelets and 5-hydroxytryptamine (5-HT)-containing neurones of the CNS point to the platelets as a reliable model for the biochemical characterization of 5-HT releasers and uptake blockers which interfere with the storage and the active carrier mechanism of 5-HT in the neurones, respectively. In addition, the affinity displayed by dopamine and by dopaminergic neurotoxin MPP+ for the platelet 5-HT transport and storage indicates also some similarities between platelets and the dopaminergic system of the CNS. Since human platelets contain almost exclusively monoamine oxidase type B (MAO-B), they can be used as a source for the purification and characterization of this human enzyme. Human platelets thus offer an excellent peripheral model to indirectly assess the degree and duration of MAO-B inhibition occurring in the CNS. To date, knowledge of the many biochemical mechanisms underlying platelet physiology is still fragmentary. In fact, the functional role of binding sites located on the platelet cytoplasmic membrane, i.e. their coupling to a specific transmembrane signalling mechanism, is still in need of a precise biochemical and physiological characterization.

MeSH Terms
Animals Blood Platelets/enzymology,metabolism,physiology,ultrastructure Humans Macaca mulatta Monoamine Oxidase/metabolism Neurons/enzymology,physiology Organoids/metabolism Receptors, Adrenergic, alpha/physiology Receptors, Angiotensin/physiology Receptors, Serotonin/physiology Receptors, Vasopressin Serotonin/metabolism,physiology
Chemicals
Receptors, Adrenergic, alpha Receptors, Angiotensin Receptors, Serotonin Receptors, Vasopressin Serotonin Monoamine Oxidase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Da Prada M
Pharmaceutical Research Department, F. Hoffmann-La Roche & Co. Ltd., Basel, Switzerland.
Cesura A M
Launay J M
Richards J G
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01952193
Published
1988-02-15
Pages
115-26
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01952193
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