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PMID: 2832109 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cyclosporin A and prednisolone do not inhibit the expression of high-affinity receptors for interleukin 2.

Clinical and experimental immunology ·Vol. 71 ·No. 2 ·1988-02-00 ·Pages 308-13

Bloemena E, Van Oers MH, Weinreich S, Schellekens PT

Abstract

To elucidate the mechanisms of action of cyclosporin A (CyA) and prednisolone (pred), we investigated the effects of these immunosuppressive drugs on the expression of receptors for interleukin 2 (IL-2) as well as the effect of exogenous IL-2 on CyA-inhibited and pred-inhibited responses. Pred-induced inhibition of T cell proliferative responses could be reversed by addition of exogenous IL-2. In contrast, exogenous IL-2 could not overcome CyA-mediated inhibition of T cell proliferation. Receptors for IL-2, as measured by the expression of Tac antigen, were slightly decreased by CyA and pred. However, expression of the biologically active, high-affinity IL-2 receptors was not diminished. These data suggest that pred-mediated inhibition occurs at the level of the IL-2 system, whereas CyA affects the proliferative mechanism of the T cell itself.

MeSH Terms
Adult Antigens, Surface/immunology Cells, Cultured Cyclosporins/pharmacology Dose-Response Relationship, Drug Humans Interleukin-2/pharmacology Lymphocyte Activation Middle Aged Mitosis/drug effects Prednisolone/pharmacology Receptors, Antigen, T-Cell/drug effects Receptors, Immunologic/drug effects Receptors, Interleukin-2 T-Lymphocytes/immunology Tumor Necrosis Factor Receptor Superfamily, Member 7
Chemicals
Antigens, Surface Cyclosporins Interleukin-2 Receptors, Antigen, T-Cell Receptors, Immunologic Receptors, Interleukin-2 Tumor Necrosis Factor Receptor Superfamily, Member 7 Prednisolone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bloemena E
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Van Oers M H
Weinreich S
Schellekens P T
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1988-02-00
Pages
308-13
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1541448
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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