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PMID: 2832152 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

KP elements repress P-induced hybrid dysgenesis in Drosophila melanogaster.

The EMBO journal ·Vol. 6 ·No. 13 ·1987-12-20 ·Pages 4125-35

Black DM, Jackson MS, Kidwell MG, Dover GA

Abstract

Molecular and genetic analysis has revealed a specific P factor deletion derivative (the KP element) which is able to repress P-induced hybrid dysgenesis. All naturally occurring strains lacking the P cytotype (M') that were examined, throughout the world contain up to 30 copies of KP per haploid genome together with complete P factors. The KP element is derived from the P factor by an internal deletion of 1753 bp removing nucleotides 808-2560 and is transcribed to yield an abundant 0.8-kb poly(A)+ RNA with the coding capacity for an in-frame 207 amino acid polypeptide. Genetic crosses show that KP elements preferentially accumulate in the presence of P factors and suppress hybrid dysgenesis. Suppression is transmitted through both sexes and is thus distinct from the maternally transmitted P cytotype mode of suppression. The spread of KP elements is probably due to the continual selection of individuals with the highest numbers of KP elements in which P-induced hybrid dysgenesis is suppressed.

MeSH Terms

Animals Base Sequence Crosses, Genetic DNA Transposable Elements Drosophila melanogaster/genetics Female Genetic Variation Hybridization, Genetic Infertility Male Molecular Sequence Data Mutation

Chemicals

DNA Transposable Elements

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Black D M

Department of Genetics, University of Cambridge, UK.

Jackson M S

Kidwell M G

Dover G A

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25 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1987-12-20

Pages

4125-35

Language

English

Region

England

NLM ID

8208664

PMCID

PMC553895

Subset

Grants

NIGMS NIH HHS · GM 36715 · United States

Databases

GENBANK

X06590

External Links

PubMed source PMC Full Text View journal details

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KP elements repress P-induced hybrid dysgenesis in Drosophila melanogaster.

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