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PMID: 283425 Published · ppublish English Journal Article

Changes in transmitter release induced by ion-containing liposomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 10 ·1978-10-00 ·Pages 5214-6

Rahamimoff R, Meiri H, Erulkar SD, Barenholz Y

Abstract

The changes in quantal transmitter release induced by egg phosphatidylcholine liposomes with different internal ionic composition were examined at the frog neuromuscular junction by using conventional electrophysiological techniques. It was found that liposomes containing calcium or sodium ions increase both evoked and spontaneous transmitter release, while liposomes containing potassium do not. The results suggest that phosphatidylcholine liposomes are able to transfer their aqueous medium into the presynaptic nerve terminal.

MeSH Terms
Acetylcholine/metabolism Calcium/metabolism Ions/metabolism Liposomes/metabolism Neuromuscular Junction/metabolism Potassium/metabolism Sodium/metabolism
Chemicals
Ions Liposomes Sodium Acetylcholine Potassium Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rahamimoff R
Meiri H
Erulkar S D
Barenholz Y
References (12)
12 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.10.5214
Published
1978-10-00
Pages
5214-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336296
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.10.5214 PMC Full Text View journal details
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