Home LiteratureArticle Details
PMID: 2834909 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Suppression of acute experimental allergic encephalomyelitis by synthetic serum thymic factor. Clinical, histopathological, and immunohistochemical studies.

Acta neuropathologica ·Vol. 75 ·No. 4 ·1988-00-00 ·Pages 337-44

Kato S, Nakamura H

Abstract

Acute experimental allergic encephalomyelitis (EAE) was induced in Hartley guinea pigs and Lewis rats, which were then treated with synthetic serum thymic factor (FTS). When a dose of 30 micrograms/100 g body weight of FTS was subcutaneously administered to the animals on days--1 (before inoculation), 4, 9 and 15 intermittently, clinical symptoms of acute EAE were suppressed. Histopathological evaluation showed that the severity of EAE in FTS-treated guinea pigs was less than in untreated guinea pigs. Immunohistochemical examination showed that the numbers of OX6+, W3/25+, W3/13+ and OX19+ cells in FTS-treated rats were less than in untreated rats and that the number of OX8+ cells in FTS-treated rats was greater than in untreated rats. These findings suggest that FTS induced OX8+ cells in inflammatory lesions and suppressed inflammation in acute EAE.

MeSH Terms
Animals Antibodies, Monoclonal Brain/immunology,ultrastructure Encephalomyelitis, Autoimmune, Experimental/drug therapy,immunology Guinea Pigs Histocompatibility Antigens Class II/analysis Immunohistochemistry Male Rats Rats, Inbred Lew T-Lymphocytes/analysis Thymic Factor, Circulating/chemical synthesis,therapeutic use Thymus Hormones/therapeutic use
Chemicals
Antibodies, Monoclonal Histocompatibility Antigens Class II Thymus Hormones Thymic Factor, Circulating
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kato S
Division of Neuropathology, Tottori University School of Medicine, Yonago, Japan.
Nakamura H
References (18)
18 references, click to expand
  1. Biochemical characterisation of a serum thymic factor.
    Nature. 1977 Mar 3;266(5597):55-7 PMID: 300146
  2. Dose-dependency of MBP-induced demyelination in the guinea pig.
    J Neurol Sci. 1985 Sep;70(2):197-205 PMID: 2414404
  3. Chronic relapsing experimental allergic encephalomyelitis: an experimental model of multiple sclerosis.
    Ann Neurol. 1977 Feb;1(2):144-8 PMID: 889297
  4. Critical threshold for dose of myelin basic protein in murine autoimmune encephalomyelitis.
    J Neurol Sci. 1987 Feb;77(2-3):173-84 PMID: 2434622
  5. Suppressor T-lymphocytes in the spinal cord of Lewis rats recovered from acute experimental allergic encephalomyelitis.
    Cell Immunol. 1984 Apr 15;85(1):284-8 PMID: 6231999
  6. Intensive suppression of experimental allergic encephalomyelitis (EAE) by serum thymic factor and therapeutic implication for multiple sclerosis.
    Jpn J Exp Med. 1982 Aug;52(4):213-9 PMID: 6983610
  7. The effects of thymosin (fraction V) on adjuvant diseases in rats.
    Thymus. 1981 Jun;3(1):51-3 PMID: 7268832
  8. Isolation, biochemical characteristics, and biological activity of a circulating thymic hormone in the mouse and in the human.
    Ann N Y Acad Sci. 1975 Feb 28;249:186-210 PMID: 1079427
  9. Regulation of theta-antigen expression by agents altering cyclic AMP level and by thymic factor.
    Ann N Y Acad Sci. 1975 Feb 28;249:316-27 PMID: 165766
  10. Characterization of T cell lines and clones from SJL/J and (BALB/c x SJL/J)F1 mice specific for myelin basic protein.
    J Immunol. 1985 Apr;134(4):2322-7 PMID: 2579139
  11. Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells.
    J Immunol. 1982 Jul;129(1):303-8 PMID: 6177753
  12. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.
    J Immunol. 1981 Oct;127(4):1420-3 PMID: 6168690
  13. Thymic function in NZB mice. II. Regulatory influence of a circulating thymic factor on antibody production against polyvinylpyrrolidone in NZB mice.
    J Immunol. 1976 Sep;117(3):760-4 PMID: 1085309
  14. Thymectomy in the young pig: effects on the level of circulating thymic hormone.
    Surgery. 1974 Oct;76(4):556-9 PMID: 4416643
  15. The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.
    Immunology. 1981 Apr;42(4):593-600 PMID: 7016746
  16. Experimental allergic encephalomyelitis in guinea pigs. Influence of thymosin fraction V on the disease.
    J Neuroimmunol. 1985 Jan;7(4):215-9 PMID: 2578135
  17. Partial reactivation of impaired immune competence in aged mice by synthetic thymus factors.
    Biochem Biophys Res Commun. 1978 Feb 14;80(3):631-6 PMID: 629796
  18. Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis.
    J Immunol. 1983 Dec;131(6):2805-9 PMID: 6605991
Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00687786
Published
1988-00-00
Pages
337-44
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00687786 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2