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PMID: 2836610 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Herpes simplex virus type 1-specific cytotoxic T lymphocytes recognize virus nonstructural proteins.

Journal of virology ·Vol. 62 ·No. 7 ·1988-07-00 ·Pages 2265-73

Martin S, Courtney RJ, Fowler G, Rouse BT

Abstract

The specificity of herpes simplex virus type 1-specific cytotoxic T cells was examined with target cells expressing either input viral structural antigens or antigens resulting from permissive infection or cells from an interrupted infection in which they expressed predominantly nonstructural immediate-early proteins. These studies indicated that only an insignificant minority of cytotoxic T cells recognized the input viral antigens, whereas a significant proportion (20 to 35%) recognized target cells that expressed the immediate-early proteins despite the absence of serologically detectable viral antigens upon the infected cell surface. The finding that a significant proportion of cytotoxic T-cell populations obtained from the draining lymph nodes of mice acutely infected with herpes simplex virus type 1 also recognized immediately-early gene-expressing target cells indicates the importance of nonstructural herpes simplex virus proteins to antiviral immunity in vivo.

MeSH Terms
Cytotoxicity, Immunologic Genes, Viral Simplexvirus/genetics,immunology T-Lymphocytes, Cytotoxic/immunology Viral Proteins/immunology
Chemicals
Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Martin S
Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37996-0845.
Courtney R J
Fowler G
Rouse B T
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.7.2265-2273.1988
Published
1988-07-00
Pages
2265-73
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253369
Subset
IM
Grants
PHS HHS · A1 14981 · United States
NCI NIH HHS · CA 42460 · United States
External Links
PubMed source DOI: 10.1128/JVI.62.7.2265-2273.1988 PMC Full Text View journal details
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